Surface Engineering of Poly(ethylene terephthalate) for Durable Hemocompatibility via a Surface Interpenetrating Network Technique

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Li, Jiang
Lin, Francis
Li, Lingdong
Li, Jing
Liu, Song
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Heparin was covalently bonded on chemically inert PET substrate using a surface modifi cation technique–surface interpenetrating network with the purpose of fabricating long-lasting biocompatible materials as vascular grafts. FTIR and XPS spectra confi rmed the successful heparinization of PET (PET-Hep). The density of surface-immobilized heparin as quantifi ed by a colorimetric method could reach 2.4 μ g cm − 2 (in the reported optimal range: 1.5–3.0 μ g cm − 2 ). The hemocompatibility of the heparin-immobilized PET was improved as evidenced by a platelet adhesion test: signifi cantly less platelet adhesion on PET-Hep (11.60%) than on untreated PET (48.91%). An MTT assay indicated PET-Hep was nontoxic to human dermal fi broblast cells. After an initial 5.24% loss of heparin from PETHep in the fi rst 14 h immersion in PBS buffer solution, no further leaching of heparin was found.
Surface Engineering of Poly(ethylene terephthalate), Surface Interpenetrating Network, Durable Hemocompatibility
Li, J.; Lin, F.; Li, L.; Li, J.; Liu, S.* Surface engineering of poly(ethylene terephthalate) for durable hemocompatibility via a surface interpenetrating network technique. Macromolecular Chemistry and Physics, 2012; 213(20): 2120–2129.