dc.contributor.author | Zhao, Nan | |
dc.contributor.author | Logsetty, Sarvesh | |
dc.contributor.author | Liu, Song | |
dc.date.accessioned | 2018-10-05T21:01:45Z | |
dc.date.available | 2018-10-05T21:01:45Z | |
dc.date.issued | 2012-07-01 | |
dc.date.submitted | 2018-10-05T20:16:13Z | en |
dc.identifier.citation | Zhao, N.; Logsetty, S.; Liu, S.* Durability of amide N-chloramine biocides to ethylene oxide sterilization. Journal of Burn Care and Research, 2012; 33(4): e201-6 | en_US |
dc.identifier.uri | http://hdl.handle.net/1993/33525 | |
dc.description.abstract | The objective of this work is to study the stability of three novel topical antimicrobial dressings
consisting of amide N-chloramine structures against ethylene oxide sterilization. Cotton gauze
samples bonded with one of three amide N-chloramine structures were subjected to standard
ethylene oxide (EtO) sterilization. The amounts of amide N-chloramine structures before and
after the sterilization were quantified to indicate the stabilities of these amide N-chloramine
structures to the sterilization. The samples after sterilization were challenged with a clinical
isolate of healthcare-associated multidrug-resistant Escherichia coli. N-Chloramine structure
converted from polymethacrylamide (dressing 2) had the highest durability (89.7% retained
active chlorine) toward EtO sterilization; that from hydantoin (dressing 3; 86.3% retained active
chlorine) followed; and poly(N-chloroacrylamide) (dressing 1) had the lowest (64.0% retained
active chlorine). After EtO sterilization, all the samples still reduced E. coli presence at 5 minutes
of contact, with dressing 2 retaining a log 6 reduction. The three tested amide N-chloramine
structures could all survive EtO sterilization while retaining percentages of active chlorine
ranging from 64.0 to 89.7%. Dressing 2 showed the best durability, whereas dressing 1 had the
poorest durability. With the remaining amounts of amide N-chloramine structures after EtO
sterilization, all the dressings could still reduce E. coli numbers within 5 minutes of contact, and
dressing 2 resulted in a log 6 reduction in colony count. | en_US |
dc.description.sponsorship | Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (RGPIN/372048-2009) | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | open access | en_US |
dc.subject | N-Chloramine | en_US |
dc.subject | biocides | en_US |
dc.subject | Ethylene Oxide Sterilization | en_US |
dc.subject | antimicrobial wound dressings | en_US |
dc.title | Durability of amide N-chloramine biocides to ethylene oxide sterilization | en_US |
dc.type | Article | en_US |
dc.identifier.doi | 10.1097/BCR.0b013e318241b31f | |
local.author.affiliation | Faculty of Agricultural and Food Sciences | en_US |