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The Efficacy of Vaporous Hydrogen Peroxide and Gaseous Chlorine Dioxide in the Detoxification of Ricin and Bacillus anthracis Lethal Factor and Protective Antigen

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dc.contributor.supervisor Court, Deborah (Microbiology)Theriault, Steven (Microbiology) en_US
dc.contributor.author Gordon Pappas, Diane
dc.date.accessioned 2012-01-17T18:50:53Z
dc.date.available 2012-01-17T18:50:53Z
dc.date.issued 2012-01-17
dc.identifier.uri http://hdl.handle.net/1993/5103
dc.description.abstract Biological toxins such as ricin and the Bacillus anthracis toxins have become an increasing bioterrorism threat due to the relative availability, extreme potency and ease of production of these agents. Extensive research has been conducted investigating methods for decontaminating spaces affected by biological agents such as bacteria and viruses, but little research has been done to determine the efficacy of these methods on toxins. The efficacy of gaseous chlorine dioxide (GCD) and vaporous hydrogen peroxide (VHP) at inactivating ricin and B. anthracis lethal factor and protective antigen was tested. The presence and activity of the toxins after exposure to the decontamination methods was detected using a cytotoxicity assay and protein gel electrophoresis. Both VHP and GCD were found to be effective at detoxifying the anthrax toxins within a short exposure, with close to complete inactivation observed during longer exposures. Ricin proved to be more resistant to inactivation, with longer exposures needed to achieve similar levels of detoxification to the anthrax toxins. Overall, GCD and VHP have great potential for use in inactivating biological toxins. en_US
dc.subject decontamination en_US
dc.subject toxins en_US
dc.title The Efficacy of Vaporous Hydrogen Peroxide and Gaseous Chlorine Dioxide in the Detoxification of Ricin and Bacillus anthracis Lethal Factor and Protective Antigen en_US
dc.degree.discipline Microbiology en_US
dc.contributor.examiningcommittee de Kievit, Teresa (Microbiology) Bernard Kathryn (Medical Microbiology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2012 en_US


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