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dc.contributor.supervisorZhanel, George (Medical Microbiology and Infectious Diseases)en_US
dc.contributor.authorTailor, Franil
dc.date.accessioned2011-09-01T18:20:20Z
dc.date.available2011-09-01T18:20:20Z
dc.date.issued2011-09-01
dc.identifier.urihttp://hdl.handle.net/1993/4824
dc.description.abstractEscherichia coli and Klebsiella pneumoniae isolates were obtained from the Canadian Ward Surveillance Study (CANWARD) and underwent in vitro susceptibility testing to determine prevalence and antimicrobial resistance patterns. The prevalence was found to be relatively stable over the years although there was an increase in prevalence among the K. pneumoniae isolates; 1.1% to 1.3% to 2.5% to 2.6% in 2007, 2008, 2009, and 2010, respectively. Genotypic characterization was conducted on ESBL, AmpC, carbapenemase genes, and outer membrane porins. The highest proportion of isolates were found to produce CTX-M-15 β-lactamase. Only 1 of each KPC-producing E. coli and K. pneumoniae was found. Porin alteration was found to be a factor leading to carbapenem reduced susceptibility among isolates. Genetic relatedness of CRS/CIR E. coli and K. pneumoniae was determined using pulsed-field gel electrophoresis. The spread of these organisms was mainly due to polyclonal spread rather than one specific clone.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectESBLen_US
dc.subjectcarbapenem-resistanten_US
dc.titleCharacterization of Escherichia coli and Klebsiella pneumoniae with resistance or reduced susceptibility to carbapenems isolated from Canadian hospitals from 2007-2010en_US
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineMedical Microbiologyen_US
dc.contributor.examiningcommitteeHoban, Daryl (Medical Microbiology and Infectious Diseases) Embree, Joanne (Medical Microbiology and Infectious Diseases) Worobec, Elizabeth (Microbiology) Mulvey, Michael (Medical Microbiology and Infectious Diseases)en_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2011en_US


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