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Phenotypic and genotypic characterization of high-level macrolide and lincosamide resistance in Corynebacterium species in Canada and the distribution of the ermX resistance determinant among Corynebacterium species

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dc.contributor.supervisor Bernard, Kathryn (Medical Microbiology) en
dc.contributor.author Singh, Cathleen
dc.date.accessioned 2010-04-12T14:53:10Z
dc.date.available 2010-04-12T14:53:10Z
dc.date.issued 2010-04-12T14:53:10Z
dc.identifier.uri http://hdl.handle.net/1993/3974
dc.description.abstract Specific bacterial commensals demonstrating multidrug resistance (MDR) are opportunistic pathogens for immunocompromised patients, including Corynebacterium species (spp.). Severe infections due to MDR corynebacteria are being increasingly reported where several MDR phenotypes have been described. One such phenotype, the macrolide-lincosamide-streptogramin B phenotype (MLSB), is characterized by high-level resistance to macrolides, lincosamides, and streptogramin B. Resistance is thought to be attributable to acquisition of the ermX gene, a methyltransferase that alters the ribosomal macrolide binding site. Until recently, ermX had been reported in only six Corynebacterium spp. We have observed other corynebacteria can also display high-level resistance to MLSB antimicrobials and are ermX positive. Hypotheses being tested include: 1) high-level macrolide and lincosamide resistance in Corynebacterium spp. is caused by acquiring ermX; 2) distribution of ermX is more widespread than previously published; 3) ermX is associated with transposon Tn5432; 4) multidrug resistance has spread to Canadian C. afermentans and C. aurimucosum strains. en
dc.format.extent 36718591 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Corynebacterium en
dc.subject macrolide en
dc.subject resistance en
dc.subject ermX en
dc.subject multidrug en
dc.subject resistant en
dc.title Phenotypic and genotypic characterization of high-level macrolide and lincosamide resistance in Corynebacterium species in Canada and the distribution of the ermX resistance determinant among Corynebacterium species en
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Medical Microbiology en
dc.contributor.examiningcommittee Alfa, Michelle (Medical Microbiology) Karlowsky, James (Medical Microbiology) Theriault, Steven (Microbiology) Zhanel, George (Medical Microbiology) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2010 en


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