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dc.contributor.supervisorBernard, Kathryn (Medical Microbiology)en
dc.contributor.authorSingh, Cathleen
dc.date.accessioned2010-04-12T14:53:10Z
dc.date.available2010-04-12T14:53:10Z
dc.date.issued2010-04-12T14:53:10Z
dc.identifier.urihttp://hdl.handle.net/1993/3974
dc.description.abstractSpecific bacterial commensals demonstrating multidrug resistance (MDR) are opportunistic pathogens for immunocompromised patients, including Corynebacterium species (spp.). Severe infections due to MDR corynebacteria are being increasingly reported where several MDR phenotypes have been described. One such phenotype, the macrolide-lincosamide-streptogramin B phenotype (MLSB), is characterized by high-level resistance to macrolides, lincosamides, and streptogramin B. Resistance is thought to be attributable to acquisition of the ermX gene, a methyltransferase that alters the ribosomal macrolide binding site. Until recently, ermX had been reported in only six Corynebacterium spp. We have observed other corynebacteria can also display high-level resistance to MLSB antimicrobials and are ermX positive. Hypotheses being tested include: 1) high-level macrolide and lincosamide resistance in Corynebacterium spp. is caused by acquiring ermX; 2) distribution of ermX is more widespread than previously published; 3) ermX is associated with transposon Tn5432; 4) multidrug resistance has spread to Canadian C. afermentans and C. aurimucosum strains.en
dc.format.extent36718591 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCorynebacteriumen
dc.subjectmacrolideen
dc.subjectresistanceen
dc.subjectermXen
dc.subjectmultidrugen
dc.subjectresistanten
dc.titlePhenotypic and genotypic characterization of high-level macrolide and lincosamide resistance in Corynebacterium species in Canada and the distribution of the ermX resistance determinant among Corynebacterium speciesen
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineMedical Microbiologyen_US
dc.contributor.examiningcommitteeAlfa, Michelle (Medical Microbiology) Karlowsky, James (Medical Microbiology) Theriault, Steven (Microbiology) Zhanel, George (Medical Microbiology)en
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteMay 2010en


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