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dc.contributor.supervisor Court, Deborah A. (Microbiology) Theriault, Steven (Microbiology) en
dc.contributor.author Cook, Bradley William Michael
dc.date.accessioned 2010-04-09T17:26:06Z
dc.date.available 2010-04-09T17:26:06Z
dc.date.issued 2010-04-09T17:26:06Z
dc.identifier.uri http://hdl.handle.net/1993/3962
dc.description.abstract Kyasanur Forest Disease Virus (KFDV) is a tick-borne, hemorrhagic fever-causing member of the Flaviviridae. With infections annually ranging from 50 to 1000 people in south-west India and the lack of effective treatments, a better understanding of this virus is needed. The development of a Reverse Genetics System for KFDV would provide the opportunity to address these issues in future studies. Using molecular techniques, the KFDV genome sequence was elucidated and the reverse genetics system was created. Utilizing this system live, infectious KFDV particles were produced from mammalian cell culture, thereby validating the success of the reverse genetics system. The implementation of this system will enable researchers to better study pathogenesis and disease progression, virus-host interplay, virion structure, genome replication and the emergence of effective therapeutics and vaccines. en
dc.format.extent 1652338 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Kyasanur Forest Disease Virus en
dc.subject Reverse Genetics en
dc.title The Molecular Characterization and The Generation of a Reverse Genetics System for Kyasanur Forest Disease Virus en
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Microbiology en
dc.contributor.examiningcommittee de Kievit, Teresa (Microbiology) Levin, David (Biosystems Engineering) Theriault, Steven (Microbiology) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2010 en


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