Potential prebiotic effect of canola meal non-starch polysaccharide hydrolysis products in weaned piglets challenged with enterotoxigenic Escherichia coli F4
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Date
2022-03-30
Authors
Zhang, Xiaoxiao
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Abstract
Weaning period is a challenging time for piglets because piglets meet many different stressors from environment and changed diet. Weaned piglets are vulnerable to postweaning diarrhea, which could lead to economic losses in the pig industry. Antibiotic growth promoters (AGPs) have been used in the pig industry for many years in order to improve growth and decrease the diarrhea of weaned piglets. However, many countries have banned and limited the use of AGPs, finding replacement to AGPs is essential. Researchers found that enzyme hydrolysis products (HP) derived from non-starch polysaccharide (NSP) may be helpful to balance the gut health in weaned piglets. Thus, our experiment was to study the effect of NSP HP extracted from diets as the alternatives to AGPs on weaned pigs. In this study, responses of weaned piglets to an oral challenge with enterotoxigenic Escherichia coli F4 (ETEC) when fed diets containing canola meal (CM) HP were investigated. The HP were obtained by incubating CM with a multi-carbohydrase (MC) blend. After challenging with ETEC F4, weaned piglets fed with HP-containing diets had higher G: F than those piglets fed without any feed additives when challenged with ETEC. Piglets fed diets containing HP showed lower jejunum pH and fecal scores than piglets fed the control diet. For gene expressions, the HP group showed a lower level of TNF-a, IL-6, toll like receptor 2 (TLR2) as well as toll like receptor 4 (TLR4) compared with non-feed additive group. Feeding HP resulted in higher BCOAF and lactobacillus in the colon digesta of piglets. In conclusion, piglets fed diets with CM NSP HP exhibited less severe ETEC-enteritis and CM NSP HP could be alternatives to AGPs.
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Keywords
Non-starch polysaccharides hydrolysis product, Piglets, Post-weaning colibacillosis