Show simple item record

dc.contributor.supervisor Wang, Jun-Feng (Pharmacology and Therapeutics) en_US
dc.contributor.author Zhou, Hong
dc.date.accessioned 2018-10-24T18:29:18Z
dc.date.available 2018-10-24T18:29:18Z
dc.date.issued 2018-10-18 en_US
dc.date.submitted 2018-10-19T02:32:18Z en
dc.identifier.citation Zhou, H., Tan, H., Letourneau, L., & Wang, J. F. (2019). Increased thioredoxin-interacting protein in brain of mice exposed to chronic stress. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 88, 320-326. en_US
dc.identifier.uri http://hdl.handle.net/1993/33535
dc.description.abstract Chronic stress is a key contributor to depression. It can cause oxidative stress which is also increased in depression. Thioredoxin (Trx) is a ubiquitous reductase that can reverse protein cystine oxidative modification, including sulfenylation and nitrosylation, and inhibit the apoptosis signal-regulating kinase 1 (ASK1) pathway. Thioredoxin-interacting protein (Txnip) is an endogenous Trx inhibitor. The chronic unpredictable stress (CUS) animal model is wildly used to mimic human depression. We found that mice exposed to CUS displayed decreased exploratory, increased anhedonic and increased despair depressive-like behaviours. Although Trx protein levels didn’t change, Txnip protein levels were significantly increased in hippocampus, frontal cortex and nucleus accumbens of CUS mice. Further investigation demonstrated an increase in protein sulfenylation, nitrosylation and ASK1 phosphorylation in CUS mice hippocampus and frontal cortex. These findings suggest that chronic stress may upregulate Txnip protein levels, subsequently inhibiting Trx activity and enhancing protein cysteine oxidative modification and the ASK1 pathway. en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject Thioredoxin en_US
dc.subject Thioredoxin-interacting protein en_US
dc.subject Chronic unpredictable stress en_US
dc.subject Sulfenylation en_US
dc.title The regulation of thioredoxin system in chronic stress-induced depression en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US
dc.degree.discipline Pharmacology and Therapeutics en_US
dc.contributor.examiningcommittee Albensi,Benedict (Pharmacology and Therapeutics) Kirouac,Gilbert (Oral Biology) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2019 en_US


Files in this item

This item appears in the following Collection(s)

Show simple item record

View Statistics