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dc.contributor.supervisor Mizuno, Tooru (Physiology and Pathophysiology) en_US
dc.contributor.author Sharma, Bhavya
dc.date.accessioned 2017-09-05T18:22:27Z
dc.date.available 2017-09-05T18:22:27Z
dc.date.issued 2017 en_US
dc.identifier.citation APA en_US
dc.identifier.uri http://hdl.handle.net/1993/32426
dc.description.abstract Xenin is a gastrointestinal hormone reported to supress food intake. Little is known about the role of xenin in body weight regulation. I hypothesized that enhanced xenin action will cause alterations in lipid metabolism towards reducing adiposity and body weight. To address this hypothesis, the present study investigated the effect of intracerebroventricular (i.c.v.) xenin treatment on body weight and lipid metabolism in obese mice. Effects of xenin on lipid metabolism were also investigated ex vivo in cultured gonadal white adipose tissue (WAT) and 3T3-L1 adipocytes. I.c.v. xenin treatment reduced body weight gain and increased phosphorylation of hormone sensitive lipase (HSL) in WAT of obese mice. Xenin treatment increased glycerol, free fatty acid (FFA) release and phosphorylation of HSL ex vivo in cultured WAT and 3T3-L1 adipocytes. These findings suggest that enhanced xenin action may be beneficial in reversing obesity by increasing the use of stored fats for fuel. en_US
dc.publisher Elsevier Ltd. en_US
dc.subject Obesity en_US
dc.subject Adipose tissue en_US
dc.title Regulation of lipid metabolism by xenin en_US
dc.degree.discipline Physiology and Pathophysiology en_US
dc.contributor.examiningcommittee Zahradka, Peter (Physiology and Pathophysiology) Mishra, Suresh (Physiology and Pathophysiology) Dolinsky, Vernon (Pharmacology and Therapeutics) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note October 2017 en_US


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