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Resuscitation, preservation, and evaluation of hearts donated after circulatory death: an avenue to expand the donor pool for transplantation

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dc.contributor.supervisor Freed, Darren (Physiology and Pathophysiology) Hryshko, Larry (Physiology and Pathophysiology) en_US
dc.contributor.author White, Christopher W.
dc.date.accessioned 2017-03-29T17:46:34Z
dc.date.available 2017-03-29T17:46:34Z
dc.date.issued 2016-03 en_US
dc.date.issued 2013-07 en_US
dc.date.issued 2015-01 en_US
dc.date.issued 2015-05 en_US
dc.date.issued 2016-03 en_US
dc.date.issued 2017-01 en_US
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dc.identifier.citation White et al. The Journal of Heart and Lung Transplantation 2013, 32 (7): 734 - 743 en_US
dc.identifier.citation White et al. The Journal of Heart and Lung Transplantation 2015, 34 (1): 113 - 121 en_US
dc.identifier.citation White et al. Canadian Journal of Physiology and Pharmacology 2015, 93 (10): 893 - 901 en_US
dc.identifier.citation White et al. American Journal of Transplantation 2015, 16 (3): 773 - 782 en_US
dc.identifier.citation White et al. The Annals of Thoracic Surgery 2017, 103(1):122-130 en_US
dc.identifier.uri http://hdl.handle.net/1993/32171
dc.description.abstract Cardiac transplantation is the treatment of choice for eligible patients with advanced heart failure; however, it is limited by a critical shortage of suitable organs from traditional brain-dead donors. Organs donated following circulatory death (DCD) have been used to successfully expand the pool of organs available for kidney, liver, and lung transplantation; however, concerns regarding the severity of injury sustained by the heart following withdrawal of life sustaining therapy have deterred the clinical transplantation of DCD hearts. Investigations aiming to optimize the resuscitation, preservation, and evaluation of DCD hearts may facilitate the development of an evidence based protocol for DCD heart transplantation that can be translated to the clinical area and expand the donor pool. Therefore, the objectives of this thesis are to develop a clinically relevant large animal model of DCD and gain a greater understanding regarding the physiologic impact of donor extubation on the DCD heart, demonstrate as a ‘proof-of-concept’ that utilizing an approach to donor heart resuscitation, preservation, and evaluation that is tailored to the DCD context can facilitate successful transplantation, and finally to investigate ways to optimize the resuscitation, preservation, and evaluation of DCD hearts for transplantation. The results of this thesis may then be used to inform the development of an evidence-based protocol for DCD heart transplantation that can be translated to the clinical area. The clinical adoption of such a protocol has the potential to expand the donor pool and improve outcomes for patients with end-stage heart failure. en_US
dc.publisher John Wiley and Sons en_US
dc.publisher Elsevier en_US
dc.publisher Elsevier en_US
dc.publisher NRC Research Press en_US
dc.publisher John Wiley and Sons en_US
dc.publisher Elsevier en_US
dc.subject Heart transplantation en_US
dc.subject Organ donation en_US
dc.subject Organ preservation en_US
dc.subject Ex vivo heart perfusion en_US
dc.subject Donation after circulatory death en_US
dc.title Resuscitation, preservation, and evaluation of hearts donated after circulatory death: an avenue to expand the donor pool for transplantation en_US
dc.degree.discipline Physiology and Pathophysiology en_US
dc.contributor.examiningcommittee Tian, Ganghong (Physiology and Pathophysiology) Dhalla, Naranjan (Physiology and Pathophysiology) Arora, Rakesh (Surgery) Wigle, Jeffrey (Biochemistry and Medical Genetics) MacDonald, Peter (University of New South Wales) en_US
dc.degree.level Doctor of Philosophy (Ph.D.) en_US
dc.description.note May 2017 en_US


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