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dc.contributor.supervisor Gruwel, Marco (Medical Microbiology) en
dc.contributor.author Szczerba, Stephen Michael
dc.date.accessioned 2009-08-24T22:44:18Z
dc.date.available 2009-08-24T22:44:18Z
dc.date.issued 2009-08-24T22:44:18Z
dc.identifier.uri http://hdl.handle.net/1993/3180
dc.description.abstract It has been suggested that infection with Chlamydia may play a role in the initiation/progression of Alzheimer’s disease (AD). To evaluate this hypothesis APP/PS transgenic mice (genetically manipulated to express AD pathology) and wild type (Wt) mice were infected with C. muridarum, and magnetic resonance imaging (MRI) and histopathology were used to assess pathological changes. Congo red staining of tissue sections demonstrated no AD plaque pathology in Wt infected and non-infected mice, while clear pathology (neuritic plaques) was seen in transgenic mice, with a trend towards higher plaque counts in the brains in the infected transgenic mice. When MRI was used to evaluate the effects of infection in vivo, hyperintensities in T2 times were observed in APP/PS infected mice compared to APP/PS control mice both at month 5 and month 20. Together these results suggest that infection with Chlamydia may accelerate the development of AD. en
dc.format.extent 9600771 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Chlamydia en
dc.subject Alzheimer's en
dc.title The use of magnetic resonance imaging to evaluate Chlamydia as an aetiological agent in Alzheimer's disease en
dc.degree.discipline Medical Microbiology en
dc.contributor.examiningcommittee Booth, Tim (Medical Microbiology)Alfa, Michelle (Medical Microbiology)Choo-Smith, Lin-P'ing (Restorative Dentistry) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note October 2009 en


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