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dc.contributor.author Zhanel, George G
dc.contributor.author DeCorby, Mel
dc.contributor.author Nichol, Kim A
dc.contributor.author Wierzbowski, Aleksandra
dc.contributor.author Baudry, Patricia J
dc.contributor.author Tailor, Franil
dc.contributor.author Lagacé-Wiens, Philippe
dc.contributor.author Walkty, Andrew
dc.contributor.author Fanella, Sergio
dc.contributor.author Larios, Oscar
dc.contributor.author Mulvey, Michael R
dc.contributor.author McCracken, Melissa
dc.contributor.author Karlowsky, James A
dc.contributor.author The Canadian Antimicrobial Resistance Alliance (CARA),
dc.contributor.author Hoban, Daryl J
dc.date.accessioned 2016-08-03T21:03:13Z
dc.date.available 2016-08-03T21:03:13Z
dc.date.issued 2009-1-1
dc.identifier.citation George G Zhanel, Mel DeCorby, Kim A Nichol, et al., “Antimicrobial Susceptibility of 6685 Organisms Isolated from Canadian Hospitals: CANWARD 2007,” Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 20, no. Suppl A, pp. 20A-30A, 2009. doi:10.1155/2009/518471
dc.identifier.uri http://dx.doi.org/10.1155/2009/518471
dc.identifier.uri http://hdl.handle.net/1993/31556
dc.description.abstract BACKGROUND: Antimicrobial resistance is a growing problem in North American hospitals as well as hospitals worldwide. OBJECTIVES: To assess the antimicrobial susceptibility patterns of commonly used agents against the 20 most common organisms isolated from Canadian hospitals. METHODS: In total, 7881 isolates were obtained between January 1, 2007, and December 31, 2007, from 12 hospitals across Canada as part of the Canadian Ward Surveillance Study (CANWARD 2007). Of these, 6685 isolates (20 most common organisms) obtained from bacteremic, urinary, respiratory and wound specimens underwent antimicrobial susceptibility testing. Susceptibility testing was assessed using the Clinical and Laboratory Standards Institute broth microdilution method. RESULTS: The most active (based upon minimum inhibitory concentration [MIC] data only) agents against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) were dalbavancin, daptomycin, linezolid, telavancin, tigecycline and vancomycin, with MICs required to inhibit the growth of 90% of organisms (MIC90) of 0.06 μg/mL and 0.06 μg/mL, 0.25 μg/mL and 0.25 μg/mL, 4 μg/mL and 1 μg/mL, 0.25 μg/mL and 0.25 μg/mL, 0.5 μg/mL and 0.25 μg/mL, and 1 μg/mL and 2 μg/mL, respectively. The most active agents against vancomycin-resistant enterococci were daptomycin, linezolid and tigecycline with MIC90s of 2 μg/mL, 4 μg/mL and 0.12 μg/mL, respectively. The most active agents against Escherichia coli were amikacin, cefepime, ertapenem, meropenem, piperacillin-tazobactam and tigecycline with MIC90s of 4 μg/mL, 2 μg/mL, 0.06 μg/mL or less, 0.12 μg/mL or less, 4 μg/mL and 1 μg/mL, respectively. The most active agents against extendedspectrum beta-lactamase-producing E coli were ertapenem, meropenem and tigecycline with MIC90s of 0.12 μg/mL or less, 0.12 μg/mL or less and 1 μg/mL, respectively. The most active agents against Pseudomonas aeruginosa were amikacin, cefepime, meropenem and piperacillin-tazobactam with MIC90s of 32 μg/mL, 32 μg/mL, 8 μg/mL and 64 μg/mL, respectively. The most active agents against Stenotrophomonas maltophilia were tigecycline and trimethoprimsulfamethoxazole and levofloxacin with MIC90s of 8 μg/mL, 8 μg/mL and 8 μg/mL, respectively. The most active agents against Acinetobacter baumannii were amikacin, fluoroquinolones (eg, levofloxacin), meropenem, and tigecycline with MIC90s of 2 μg/mL or less, 1 μg/mL, 4 μg/mL and 2 μg/mL, respectively. CONCLUSIONS: The most active agents versus Gram-positive cocci from Canadian hospitals were vancomycin, linezolid, daptomycin, tigecycline, dalbavancin and telavancin. The most active agents versus Gram-negative bacilli from Canadian hospitals were amikacin, cefepime, ertapenem (not P aeruginosa), meropenem, piperacillintazobactam and tigecycline (not P aeruginosa). Colistin (polymyxin E) was very active against P aeruginosa and A baumannii.
dc.title Antimicrobial Susceptibility of 6685 Organisms Isolated from Canadian Hospitals: CANWARD 2007
dc.type Journal Article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.date.updated 2016-08-03T07:44:08Z


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