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Effects of dietary oils low in n-6:n-3 fatty acid ratio on cardiovascular risk in mice: the impact of the source of n-3 fatty acids

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dc.contributor.supervisor Moghadasian, Mohammed (Human Nutritional Sciences) en
dc.contributor.author Riediger, Natalie Diane
dc.date.accessioned 2008-09-16T01:21:39Z
dc.date.available 2008-09-16T01:21:39Z
dc.date.issued 2008-09-16T01:21:39Z
dc.identifier.uri http://hdl.handle.net/1993/3090
dc.description.abstract The impact of the source of n-3 fatty acids on cardiovascular disease has not been fully investigated. This study was carried out to investigate cardiovascular benefits of diets with a low ratio (2:1) of n-6:n-3 fatty acids from different sources, either fish or flaxseed oil, in C57BL/6 mice. Twenty-one mice were divided into 3 groups (n=7) and fed an atherogenic diet supplemented with either a fish or flaxseed oil-based ‘designer oil’ with low n-6:n-3 fatty acid ratio (treated groups) or safflower oil-based formulation with a high ratio (control group) for 16 weeks. Plasma cholesterol levels declined significantly in both treated groups, by greater than 30%, compared to those in control. The ratio of n-6:n-3 fatty acids in liver was significantly lower in fish and flax groups as compared to control. Our data suggest that lowering dietary ratio of n-6:n-3 fatty acids may significantly reduce cardiovascular risks regardless of the source of n-3 fatty acids. en
dc.format.extent 777057 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.subject flaxseed oil en
dc.subject fish oil en
dc.title Effects of dietary oils low in n-6:n-3 fatty acid ratio on cardiovascular risk in mice: the impact of the source of n-3 fatty acids en
dc.type info:eu-repo/semantics/masterThesis
dc.degree.discipline Human Nutritional Sciences en
dc.contributor.examiningcommittee Suh, Miyoung (Human Nutritional Sciences) Friel, James (Human Nutritional Sciences) Beta, Trust (Food Science) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note October 2008 en


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