Body Mass and Composition Affect Bone Density in Recently Diagnosed Inflammatory Bowel Disease: The Manitoba IBD Cohort Study

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dc.contributor.author Leslie, William
dc.contributor.author Miller, Norine
dc.contributor.author Rogala, Linda
dc.contributor.author Bernstein, Charles N.
dc.date.accessioned 2015-05-11T17:30:37Z
dc.date.available 2015-05-11T17:30:37Z
dc.date.issued 2009-01
dc.identifier.citation Inflamm Bowel Dis. 2009 Jan;15(1):39-46 en_US
dc.identifier.uri http://hdl.handle.net/1993/30419
dc.description.abstract BACKGROUND: This prospective study was undertaken to clarify the role of body mass and composition as a determinant of bone mineral density (BMD) in recently diagnosed inflammatory bowel disease (IBD). METHODS: A nested subgroup of 101 adult subjects of the population-based Manitoba IBD Cohort Study were enrolled. Baseline BMD and body composition were measured and repeated 2.3 +/- 0.3 years later. RESULTS: Greater weight, height, and body mass measurements were positively correlated with bone density at all sites (P < 0.01). Although both fat tissue and lean tissue showed positive relationships with BMD, lean tissue showed a much stronger correlation than fat tissue, especially for the total hip (r = 0.66, P < 0.001 versus r = 0.23, P < 0.05) and total body measurements (r = 0.59, P < 0.001 versus r = 0.04, P NS). Increase (or decrease) in hip bone density was strongly associated with an increase (or decrease) in all body mass variables (r = 0.49-0.54, P < 0.001). CONCLUSIONS: Measures of body mass are important determinants of baseline BMD in recently diagnosed IBD patients. Furthermore, change in body mass is correlated with change in BMD, especially at the total hip. Early optimization and maintenance of nutrition and body weight, particularly toward lean tissue mass, may play an important role in preventing IBD-related bone disease. en_US
dc.language.iso en en_US
dc.publisher Inflammatory Bowel Diseases en_US
dc.relation.ispartofseries 15(1);39-46
dc.subject Body mass en_US
dc.subject Bone Density en_US
dc.subject Inflammatory Bowel Disease en_US
dc.subject IBD en_US
dc.subject Bernstein en_US
dc.subject Inflammatory Bowel Disease en_US
dc.title Body Mass and Composition Affect Bone Density in Recently Diagnosed Inflammatory Bowel Disease: The Manitoba IBD Cohort Study en_US
dc.type Article en_US
dc.type Dataset en_US
dc.identifier.doi 10.1002/ibd.20541

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