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The potential of proton magnetic resonance spectroscopy (1H MRS) in detecting early colonic inflammation and assessing the effect of various dietary fatty acids on modulation of inflammatory bowel disease in an animal model

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dc.contributor.supervisor Bezabeh, Tedros (Human Nutritional Sciences) Eskin, Michael (Human Nutritional Sciences) en
dc.contributor.author Varma, Sonal
dc.date.accessioned 2008-05-14T21:27:24Z
dc.date.available 2008-05-14T21:27:24Z
dc.date.issued 2008-05-14T21:27:24Z
dc.identifier.citation Varma, S, Bird, R, Eskin, M, Dolenko, B, Raju, J, Bezabeh, T. (2007). Detection of inflammatory bowel disease by proton magnetic resonance spectroscopy (1H MRS) using an animal model. J Inflamm 26 (4): 24-30. en
dc.identifier.uri http://hdl.handle.net/1993/3039
dc.description.abstract The objectives of our study were to determine the potential of 1H MRS in detecting (1) early colonic inflammation, (2) effects of various fatty acids on normal colon and (3) their effects on IBD. Sprague dawley rat fed with 2% carrageenan was used as a model of IBD. Flaxseed oil served as ω-3, corn oil as ω-6 and beef tallow as saturated fatty acid sources. Control group animals were fed 5% corn oil, whereas, those in high-fat diet groups received an additional 7% of the respective fatty acids. After 2 weeks, 1H MRS and histology were conducted on excised colonic mucosa. Statistical classification strategy (SCS) used for analyzing 1H MRS data achieved an accuracy of 82 % in stage 1, 90-100% in stage 2 and 96-100% in stage 3. This implies that 1H MRS is a sensitive tool to diagnose early IBD and the effects of dietary fat on IBD. en
dc.format.extent 951534 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Beef tallow en
dc.subject Colon cancer en
dc.subject Corn oil en
dc.subject Flaxseed oil en
dc.subject Inflammatory bowel disease en
dc.subject Proton magnetic resonance spectroscopy en
dc.subject Statistical classification strategy en
dc.subject ω-3 polyunsaturated fatty acids en
dc.title The potential of proton magnetic resonance spectroscopy (1H MRS) in detecting early colonic inflammation and assessing the effect of various dietary fatty acids on modulation of inflammatory bowel disease in an animal model en
dc.degree.discipline Human Nutritional Sciences en
dc.contributor.examiningcommittee Begleiter, Asher (Pharmacology) Taylor, Carla (Human Nutritional Sciences) en
dc.degree.level Master of Science (M.Sc.) en
dc.description.note May 2008 en


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