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dc.contributor.supervisorCourt, Deborah (Microbiology)en_US
dc.contributor.authorMotnenko, Anna
dc.date.accessioned2014-08-21T17:06:27Z
dc.date.available2014-08-21T17:06:27Z
dc.date.issued2014-08-21
dc.identifier.urihttp://hdl.handle.net/1993/23838
dc.description.abstractMitochondria are essential organelles in the cell. They are enveloped by a two membrane system, an inner and outer membrane. Residing in the outer membrane is the voltage-dependant anion-selective channel (VDAC) which is in very high abundance in the outer membrane. Previously, when VDAC was deleted in N. crassa the mitochondria developed unusual morphology and the fungus became temperature sensitive. This was suspected to be caused by alterations in the membrane architecture. It was found that deletion of VDAC causes a reduction in mitochondrial outer membrane fluidity leading to a fragile outer membrane. In the current study it was also found that loss of VDAC significantly impacts the mitochondrial proteome. These results taken together suggest that VDAC is not only a channel for traversing the outer membrane but appears to be important for the structural integrity of the mitochondria.en_US
dc.language.isoengen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVDACen_US
dc.subjectmitochondriaen_US
dc.subjectmembraneen_US
dc.subjectfluidityen_US
dc.titleThe effects of the deletion of VDAC on the physical properties and proteome of the mitochondrial outer membrane in Neurospora crassaen_US
dc.typeinfo:eu-repo/semantics/masterThesis
dc.typemaster thesisen_US
dc.degree.disciplineMicrobiologyen_US
dc.contributor.examiningcommitteeDibrov, Pavel (Microbiology) Khajehpour, Mazdak (Chemistry)en_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.noteOctober 2014en_US


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