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dc.contributor.author Walker, Simon R
dc.contributor.author Gill, Kamalpreet
dc.contributor.author Macdonald, Kerry
dc.contributor.author Komenda, Paul
dc.contributor.author Rigatto, Claudio
dc.contributor.author Sood, Manish M
dc.contributor.author Bohm, Clara J
dc.contributor.author Storsley, Leroy J
dc.contributor.author Tangri, Navdeep
dc.date.accessioned 2014-04-05T12:18:46Z
dc.date.available 2014-04-05T12:18:46Z
dc.date.issued 2013-10-22
dc.identifier.citation BMC Nephrology. 2013 Oct 22;14(1):228
dc.identifier.uri http://hdl.handle.net/1993/23406
dc.description.abstract Abstract Background Frailty is a condition characterized by a decline in physical function and functional capacity. Common symptoms of frailty, such as weakness and exhaustion, are prevalent in patients with chronic kidney disease (CKD). The increased vulnerability of frail patients with coexisting CKD may place them at a heightened risk of encountering additional health complications. The purpose of this systematic review was to explore the link between frailty, CKD and clinical outcomes. Methods We searched for cross sectional and prospective studies in the general population and in the CKD population indexed in EMBASE, Pubmed, Web of Science, CINAHL, Cochrane and Ageline examining the association between frailty and CKD and those relating frailty in patients with CKD to clinical outcomes. Results We screened 5,066 abstracts and retrieved 108 studies for full text review. We identified 7 studies associating frailty or physical function to CKD. From the 7 studies, we identified only two studies that related frailty in patients with CKD to a clinical outcome. CKD was consistently associated with increasing frailty or reduced physical function [odds ratios (OR) 1.30 to 3.12]. In patients with CKD, frailty was associated with a greater than two-fold higher risk of dialysis and/or death [OR from 2.0 to 5.88]. Conclusions CKD is associated with a higher risk of frailty or diminished physical function. Furthermore, the presence of frailty in patients with CKD may lead to a higher risk of mortality. Further research must be conducted to understand the mechanisms of frailty in CKD and to confirm its association with clinical outcomes.
dc.rights info:eu-repo/semantics/openAccess
dc.title Association of frailty and physical function in patients with non-dialysis CKD: a systematic review
dc.type Journal Article
dc.type info:eu-repo/semantics/article
dc.language.rfc3066 en
dc.description.version Peer Reviewed
dc.rights.holder Simon R Walker et al.; licensee BioMed Central Ltd.
dc.date.updated 2014-04-05T12:18:47Z
dc.identifier.doi http://dx.doi.org/10.1186/1471-2369-14-228


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