Show simple item record Wong, Garret Drew en_US 2007-05-17T12:39:09Z 2007-05-17T12:39:09Z 1998-09-01T00:00:00Z en_US
dc.description.abstract To better understand humoral immunity against respiratory syncytial virus (RSV) and the role of serum antibodies to the surface fusion (F) glycoprotein in disease severity and protection, a large database consisting of collected sera and patient information was analyzed using plaque reduction neutralization and F antigen ELISA assays. Out of 73 infected and 73 non-infected infants with cardiopulmonary disease (matched for age and underlying disease), neutralizing antibody titers $\ge$1:100 and ELISA titers $\ge$1:10,000 were significantly correlated with a decreased incidence of RSV infection. The neutralization and ELISA assays also correlated highly when compared to each other. Acute sera samples from previously healthy infants for whom infecting subgroup was known (82 infected with subgroup A, 127 infected with subgroup B) were also analyzed as above, and an age $<$13 weeks was found to be significantly associated with severe RSV disease. As well, those infants infected with subgroup B, having an F ELISAtiter $>$1:1000 had a 5 fold less incidence of hypoxia, independent of age. Out of 45 subgroup A infected and 99 subgroup B infected infants and children for which paired acute - convalescent sera were collected, young age was significantly associated with a poor convalescent antibody response. For B infected infants only, neutralizing antibody titers $<$1:40 against subgroup B were significantly associated with a poor homologous response. Collectively, these results contribute to the understanding of humoral immunity to RSV. en_US
dc.format.extent 4695973 bytes
dc.format.extent 184 bytes
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dc.language en en_US
dc.language.iso en_US
dc.rights info:eu-repo/semantics/openAccess
dc.title Human humoral immunity to respiratory syncytial virus, correlates of disease severity and protection en_US
dc.type info:eu-repo/semantics/masterThesis
dc.type master thesis en_US Medical Microbiology en_US Master of Science (M.Sc.) en_US

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