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dc.contributor.supervisor Martin, Melanie (Physics and Astronomy) Bidinosti, Chris (Physics and Astronomy) en_US
dc.contributor.author Herrera, Sheryl Lyn
dc.date.accessioned 2012-12-17T17:38:59Z
dc.date.available 2012-12-17T17:38:59Z
dc.date.issued 2012-12-17
dc.identifier.uri http://hdl.handle.net/1993/13691
dc.description.abstract Covert stroke (CS) comprises lesions in the brain often associated by risk factors such as a diet high in fat, salt, cholesterol and sugar (HFSCS). Developing a rodent model for CS incorporating these characteristics is useful for developing and testing interventions. The purpose of this thesis was to determine if magnetic resonance (MR) can detect brain abnormalities to confirm this model will have the desired anatomical effects. Ex vivo MR showed brain abnormalities for rats with the induced lesions and fed the HFSCS diet. Spectra acquired on the fixed livers had an average percent area under the fat peak relative to the water peak of (20±4)% for HFSCS and (2±2)% for control. In vivo MR images had significant differences between surgeries to induce the lesions (p=0.04). These results show that applying MR identified abnormalities in the rat model and therefore is important in the development of this CS rodent model. en_US
dc.subject MRI en_US
dc.subject segmentation en_US
dc.subject medical physics en_US
dc.subject stroke en_US
dc.subject rodent model en_US
dc.subject magnetic resonance spectroscopy en_US
dc.title Magnetic resonance imaging and magnetic resonance spectroscopy characterize a rodent model of covert stroke en_US
dc.degree.discipline Physics and Astronomy en_US
dc.contributor.examiningcommittee Elhami, Esmat (Physics and Astronomy) Lin, Francis (Physics and Astronomy) Civetta, Alberto (Biochemistry & Medical Genetics) en_US
dc.degree.level Master of Science (M.Sc.) en_US
dc.description.note February 2013 en_US


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