Glucose disposal by insulin, but not IGF-1, is dependent on the hepatic parasympathetic nerves

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dc.contributor.authorSadri, P
dc.contributor.authorLautt, WW
dc.date.accessioned2008-01-21T18:04:27Z
dc.date.available2008-01-21T18:04:27Z
dc.date.issued2000-10-31
dc.description.abstractInsulin-like growth factor-1 (IGF-1) has many insulin-like activities, including stimulation of glucose uptake in skeletal muscle. However, those with diabetes or chronic liver disease are insulin resistant but show a normal hypoglycemic response to IGF-1. We have previously shown that insulin sensitivity depends on a hepatic parasympathetic reflex release of a hormone from the liver. The hypothesis was tested that insulin action, but not IGF-1 action, is dependent on the hepatic parasympathetic reflex. Glucose disposal in response to three doses of IGF-1 (25, 100, 200 mu g/kg) was determined in rats. IGF-1 at 200 mu g/kg had similar effect on glucose disposal as did 50 mU/kg of insulin. Interruption of the hepatic parasympathetic reflex either by surgical ablation of the anterior nerve plexus or by atropine (1.0 mg/kg) resulted in insulin, but not IGF-1, resistance. Sixteen hours of fasting resulted in insulin, but not IGF-1, resistance. In conclusion, insulin, but not IGF-1, triggers the hepatic parasympathetic dependent release of a putative hepatic insulin sensitizing substance (HISS) that stimulates glucose uptake in skeletal muscle.en
dc.format.extent161553 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citation0008-4212; CAN J PHYSIOL PHARMACOL, OCT 2000, vol. 78, no. 10, p.807 to 812.en
dc.identifier.doihttp://dx.doi.org/10.1139/y00-060
dc.identifier.urihttp://hdl.handle.net/1993/3008
dc.language.isoengen_US
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dc.rightsopen accessen_US
dc.statusPeer revieweden
dc.subjectHISSen
dc.subjectRISTen
dc.subjectatropineen
dc.subjectinsulin sensitivityen
dc.subjectfastingen
dc.subjectGROWTH-FACTOR-Ien
dc.subjectSENSITIVITYen
dc.subjectMETABOLISMen
dc.subjectRESISTANCEen
dc.subjectBLOCKADEen
dc.subjectRATSen
dc.subjectCIRRHOSISen
dc.titleGlucose disposal by insulin, but not IGF-1, is dependent on the hepatic parasympathetic nervesen
dc.typejournal articleen_US
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