HMG-CoA reductase inhibitors do not attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits
| dc.contributor.author | Kumar, Kanwal K. | |
| dc.contributor.examiningcommittee | Kardami, Elissavet (Human Anatomy & Cell Science) Freed, Darren H. (Surgery) | en_US |
| dc.contributor.supervisor | Arora, Rakesh C. (Surgery) Jassal, Davinder S. (Physiology) | en_US |
| dc.date.accessioned | 2013-01-17T14:23:09Z | |
| dc.date.available | 2013-01-17T14:23:09Z | |
| dc.date.issued | 2013-01-17 | |
| dc.degree.discipline | Surgery | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Evidence suggests that there is an immunological response of the recipient to xenograft bioprosthetic heart valves. Information on the impact of HMG-CoA reductase inhibitors (statins) and their anti-inflammatory properties on bioprosthetic valve failure remains limited. We sought to examine the efficacy of statin therapy in a rodent model of bioprosthetic valve implantation. To mimic the human scenario, fresh or glutaraldehyde-fixed aortic valve root conduits from Lewis rats or Hartley guinea pigs were microsurgically implanted intravascularly into the infra-renal aorta of Lewis rats. The syngeneic control group consisted of a fresh rat valve conduit implanted into a rat. The xenogeneic control group consisted of a glutaraldehyde-fixed guinea pig valve conduit implanted into a rat. Treatment groups consisted of xenogeneic groups treated with either daily steroids or statins. Overall, steroid treatment attenuated the inflammatory response observed within the xenogeneic glutaraldehyde-fixed valve conduits. Treatment with statins did not decrease this inflammatory response. | en_US |
| dc.description.note | February 2013 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/14909 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Cardiac Surgery | en_US |
| dc.subject | Bioprosthetic Valve | en_US |
| dc.subject | HMG-CoA reductase inhibitors | en_US |
| dc.subject | Statin | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | In vivo Rodent Model | en_US |
| dc.title | HMG-CoA reductase inhibitors do not attenuate the inflammatory response associated with glutaraldehyde-fixed bioprosthetic heart valve conduits | en_US |
| dc.type | master thesis | en_US |