Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil

Ramprasath, Vanu R; Eyal, Inbal; Zchut, Sigalit; Jones, Peter JH

Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil

dc.contributor.author	Ramprasath, Vanu R
dc.contributor.author	Eyal, Inbal
dc.contributor.author	Zchut, Sigalit
dc.contributor.author	Jones, Peter JH
dc.date.accessioned	2014-04-02T10:44:38Z
dc.date.available	2014-04-02T10:44:38Z
dc.date.issued	2013-12-05
dc.date.updated	2014-04-02T10:44:38Z
dc.description.abstract	Abstract Background Due to structural differences, bioavailability of krill oil, a phospholipid based oil, could be higher than fish oil, a triglyceride-based oil, conferring properties that render it more effective than fish oil in increasing omega-3 index and thereby, reducing cardiovascular disease (CVD) risk. Objective The objective was to assess the effects of krill oil compared with fish oil or a placebo control on plasma and red blood cell (RBC) fatty acid profile in healthy volunteers. Participants and methods Twenty four healthy volunteers were recruited for a double blinded, randomized, placebo-controlled, crossover trial. The study consisted of three treatment phases including krill or fish oil each providing 600 mg of n-3 polyunsaturated fatty acids (PUFA) or placebo control, corn oil in capsule form. Each treatment lasted 4 wk and was separated by 8 wk washout phases. Results Krill oil consumption increased plasma (p = 0.0043) and RBC (p = 0.0011) n-3 PUFA concentrations, including EPA and DHA, and reduced n-6:n-3 PUFA ratios (plasma: p = 0.0043, RBC: p = 0.0143) compared with fish oil consumption. Sum of EPA and DHA concentrations in RBC, the omega-3 index, was increased following krill oil supplementation compared with fish oil (p = 0.0143) and control (p < 0.0001). Serum triglycerides and HDL cholesterol concentrations did not change with any of the treatments. However, total and LDL cholesterol concentrations were increased following krill (TC: p = 0.0067, LDL: p = 0.0143) and fish oil supplementation (TC: p = 0.0028, LDL: p = 0.0143) compared with control. Conclusions Consumption of krill oil was well tolerated with no adverse events. Results indicate that krill oil could be more effective than fish oil in increasing n-3 PUFA, reducing n-6:n-3 PUFA ratio, and improving the omega-3 index. Trial registration ClinicalTrials.gov, NCT01323036
dc.description.version	Peer Reviewed
dc.identifier.citation	Lipids in Health and Disease. 2013 Dec 05;12(1):178
dc.identifier.doi	http://dx.doi.org/10.1186/1476-511X-12-178
dc.identifier.uri	http://hdl.handle.net/1993/23358
dc.language.rfc3066	en
dc.rights	open access	en_US
dc.rights.holder	Vanu R Ramprasath et al.; licensee BioMed Central Ltd.
dc.title	Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil
dc.type	Journal Article