Anti-gravity exercise, creatine supplementation, and serum S100A8/A9 in knee osteoarthritis

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dc.contributor.authorZhang, Pengyu
dc.contributor.examiningcommitteeGhavami, Saeid (Human Anatomy and Cell Science) Cornish, Stephen (Kinesiology and Recreation Management)en_US
dc.contributor.supervisorPeeler, Jason (Human Anatomy and Cell Science)en_US
dc.date.accessioned2018-07-10T13:49:17Z
dc.date.available2018-07-10T13:49:17Z
dc.date.issued2018en_US
dc.date.submitted2018-06-28T16:24:48Zen
dc.degree.disciplineHuman Anatomy and Cell Scienceen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractKnee osteoarthritis (OA) is a degenerative joint disease defined by the breakdown of cartilage with pain, stiffness, and swelling. An inflammatory process could be involved during the progression, and S100A8/A9 is considered a hallmark cytokine. With Lower Body Positive Pressure (LBPP) anti-gravity treadmill exercise, knee OA patients can walk with normal gait. Creatine monohydrate supplementation can decrease inflammation and improve the muscle strength. The central hypotheses stated was: inflammation associated with knee OA is related to serum S100A8/A9 level. The aims of this study focused on the effect of interventions and the level of serum S100A8/A9. Twenty-six (26) overweight participants with a mean age of 57 years were randomized into LBPP exercise, creatine supplementation, and control groups. KOOS scores, BMI, ROM, pain VAS score, and serum biomarkers were assessed. Statistical analysis indicated LBPP and Creatine could help to improve the function and disability. However the biomarkers were in normal range and not correlated to interventions.en_US
dc.description.noteOctober 2018en_US
dc.identifier.urihttp://hdl.handle.net/1993/33090
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectHuman Anatomy and Cell Scienceen_US
dc.subjectOsteoarthritisen_US
dc.subjectLower body positive pressureen_US
dc.subjectS100A8/A9en_US
dc.subjectCreatineen_US
dc.titleAnti-gravity exercise, creatine supplementation, and serum S100A8/A9 in knee osteoarthritisen_US
dc.typemaster thesisen_US
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