Proteomics in acute kidney injury—current status and future promise

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dc.contributor.authorHo, Julie
dc.contributor.authorDart, Allison
dc.contributor.authorRigatto, Claudio
dc.date.accessioned2020-09-11T22:03:18Z
dc.date.available2020-09-11T22:03:18Z
dc.date.issued2013-04-18
dc.date.submitted2020-09-11T17:20:52Zen_US
dc.description.abstractPediatric acute kidney injury (AKI) is associated with increased morbidity, mortality and associated healthcare costs. Unfortunately, there are currently no effective therapies available, and this has been attributed in part to the late diagnosis of AKI. Therefore, significant efforts have been made to develop early diagnostic tools for AKI in the hope that early identification of renal injury will allow for effective therapeutic intervention. Different transcriptomic, proteomic and metabolomic technologies offer unbiased approaches to identifying novel biomarkers of AKI. This review will provide an overview of non-invasive pediatric AKI biomarkers. It will focus on unbiased technologies by using examples of biomarkers identified with “-omic” technologies and different methodological and implementation challenges will be highlighted. Finally, emerging proteomic techniques that may be applicable to biomarker discovery will be presented. Ultimately, the development of novel biomarkers of AKI may lead to the early diagnosis and effective therapeutic intervention of AKI to improve patient outcomes.en_US
dc.description.sponsorshipCanadian Institutes of Health Research. The Kidney Foundation of Canada. KRESCENT New Investigator Program.en_US
dc.identifier.citationPediatr Nephrol 29(2):163-171, 2014en_US
dc.identifier.doi10.1007/s00467-013-2415-x
dc.identifier.urihttp://hdl.handle.net/1993/35054
dc.language.isoengen_US
dc.publisherSpringeren_US
dc.rightsopen accessen_US
dc.subjectBiomarkeren_US
dc.subjectNon-invasive diagnosisen_US
dc.subjectTranscriptomicsen_US
dc.subjectCatabolomicsen_US
dc.subjectMetabolomicsen_US
dc.titleProteomics in acute kidney injury—current status and future promiseen_US
dc.typeresearch articleen_US
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