The altered gut microbiome in metabolic syndrome

dc.contributor.authorHartmann, Riley James
dc.contributor.examiningcommitteeAlfa, Michelle (Medical Microbiology) Ghia, Jean-Eric (Immunology)en_US
dc.contributor.supervisorKhafipour, Ehsan (Medical Microbiology)en_US
dc.date.accessioned2015-04-06T19:07:25Z
dc.date.available2015-04-06T19:07:25Z
dc.date.issued2015-04-06
dc.degree.disciplineMedical Microbiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractMetabolic syndrome is a disease affecting 25% of North America’s population causing strain on the medical systems. With diet and exercise, genetics, environment, and the gut microbiota all being targeted as potential causes of the disease, there is a lack of consensus on the exact aetiology and pathophysiology. With improved methods in bioinformatic sequencing of faecal bacterial DNA in recent years, our research indicates that a dysbiosis in the gut microbiome is both necessary and sufficient in causing immunological changes in the host in order for the development of metabolic syndrome, T1Ds, and T2Ds. Specifically, our data indicates these shifts in microbiota occur prior to the onset of disease, and produce the disease regardless of diet and genetics. The findings in the current study indicate that future research towards manipulating the gut microbiota to prevent disease, as well as using the faecal bacteria as a screening tool should be pursued.en_US
dc.description.noteMay 2015en_US
dc.identifier.urihttp://hdl.handle.net/1993/30345
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectmicrobiomeen_US
dc.subjectmetabolic syndomeen_US
dc.subjectbioinformaticsen_US
dc.subjectguten_US
dc.subjectfaecalen_US
dc.titleThe altered gut microbiome in metabolic syndromeen_US
dc.typemaster thesisen_US
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