Effects of maternal diets on birth outcomes, brain lipids and apoptosis in rats exposed to ethanol during gestation

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dc.contributor.authorWang, Yidi
dc.contributor.examiningcommitteeBlewett, Heather (Food and Human Nutritional Sciences)en_US
dc.contributor.examiningcommitteeAlbensi, Benedict (Pharmacology and Therapeutics)en_US
dc.contributor.supervisorSuh, Miyoung (Food and Human Nutritional Sciences)en_US
dc.date.accessioned2020-09-03T16:07:54Z
dc.date.available2020-09-03T16:07:54Z
dc.date.copyright2020-08-14
dc.date.issued2020-08-14en_US
dc.date.submitted2020-08-14T23:23:25Zen_US
dc.degree.disciplineFood and Human Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractMaternal nutritional status is an important determinant of the severity of fetal alcohol spectrum disorders (FASD). This study examined the effects of a standard chow and a semi-purified energy dense (E-dense) diet on birth outcomes and brain lipids in rats with prenatal ethanol (EtOH) exposure. Sprague-Dawley rats were randomly assigned into four groups: chow, chow+EtOH (20% v/v), E-dense, and E-dense+EtOH. EtOH decreased body weight in chow-fed dams and litter sizes in both diet groups. At postnatal day 7, maternal E-dense diet increased body and liver weights and plasma lipids, but decreased relative brain weights and docosahexaenoic acid in the cerebellum and hippocampus of pups compared to those from chow-fed dams. No significant changes were observed on ceramides. While the long-lasting effect of maternal E-dense diet in pups is unknown, this study highlights the importance of maternal nutrition on offspring growth and suggests it as a potential strategy for alleviating FASD.en_US
dc.description.noteOctober 2020en_US
dc.identifier.urihttp://hdl.handle.net/1993/34948
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectPrenatal ethanol exposureen_US
dc.subjectMaternal dieten_US
dc.subjectBirth outcomesen_US
dc.subjectCeramidesen_US
dc.subjectApoptosisen_US
dc.titleEffects of maternal diets on birth outcomes, brain lipids and apoptosis in rats exposed to ethanol during gestationen_US
dc.typemaster thesisen_US
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