T Lymphocyte Immunity in Host Defence against Chlamydia trachomatis and Its Implication for Vaccine Development

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dc.contributor.authorYang, X
dc.contributor.authorBrunham, RC
dc.date.accessioned2016-06-09T16:46:33Z
dc.date.available2016-06-09T16:46:33Z
dc.date.issued1998-1-1
dc.date.updated2016-06-07T07:03:06Z
dc.description.abstractChlamydia trachomatis is an obligate intracellular bacterial pathogen that causes several significant human infectious diseases, including trachoma, urethritis, cervicitis and salpingitis, and is an important cofactor for transmission of human immunodeficiency virus. Until very recently, over three decades of research effort aimed at developing a C trachomatis vaccine had failed, due mainly to the lack of a precise understanding of the mechanisms for protective immunity. Although most studies concerning protective immunity to C trachomatis have focused on humoral immune responses, recent studies have clearly shown that T helper-1 (Th1)-like CD4 T cell-mediated immune responses play the dominant role in protective immunity. These studies suggest a paradigm for chlamydial immunity and pathology based on the concept of heterogeneity (Th1/Th2) in CD4 T cell immune responses. This concept for chlamydial immunity offers a rational template on which to base renewed efforts for development of a chlamydial vaccine that targets the induction of cell-mediated Th1 immune responses.
dc.description.versionPeer Reviewed
dc.identifier.citationX Yang and RC Brunham, “T Lymphocyte Immunity in Host Defence against Chlamydia trachomatis and Its Implication for Vaccine Development,” Canadian Journal of Infectious Diseases, vol. 9, no. 2, pp. 99-109, 1998. doi:10.1155/1998/395297
dc.identifier.urihttp://dx.doi.org/10.1155/1998/395297
dc.identifier.urihttp://hdl.handle.net/1993/31466
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleT Lymphocyte Immunity in Host Defence against Chlamydia trachomatis and Its Implication for Vaccine Development
dc.typeJournal Article
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