Exploring the integration of expanded carrier screening within Canadian fertility clinics

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dc.contributor.authorMorello, Michelle
dc.contributor.examiningcommitteeDriedger, Michelle (Community Health Science)
dc.contributor.examiningcommitteeSroka, Hana (Biochemistry and Medical Genetics)
dc.contributor.examiningcommitteeLiu, Xiao-Qing (Biochemistry and Medical Genetics)
dc.contributor.supervisorHartley, Jessica
dc.contributor.supervisorCarriles-Landry, Claudia
dc.date.accessioned2024-01-10T20:43:32Z
dc.date.available2024-01-10T20:43:32Z
dc.date.issued2023-12-18
dc.date.submitted2023-12-19T04:48:13Zen_US
dc.degree.disciplineBiochemistry and Medical Geneticsen_US
dc.degree.levelMaster of Science (M.Sc.)
dc.description.abstractTraditionally, carrier screening targeted individuals with family histories of genetic conditions or from specific ethnic backgrounds. However, this method is increasingly considered inadequate for accurate risk assessments. Expanded Carrier Screening (ECS) is a genetic test designed to screen for hundreds of autosomal recessive and X-linked inherited disorders to provide families with valuable information for reproductive decision-making. As guidelines across the world are being updated to incorporate recommendations for ECS provision, Canada has yet to establish such guidelines to aid providers in navigating ECS delivery. Previous studies have found that Fertility Healthcare Providers (FHP) are proponents of ECS and have the most opportunity to integrate this test into their practice, as they follow primarily a preconception cohort. Therefore, this study was designed to apply qualitative interviews to explore the experiences, perspectives and practices of Canadian FHP regarding ECS. This study interviewed six physicians and five genetic counsellors working in a fertility clinic across Canada on ECS and revealed four significant categories using a qualitative descriptive approach. Inconsistencies were observed in the provision of ECS across fertility clinics, although more standardized practices were noted among patients using donor gametes. Participants identified significant challenges and barriers to implementing ECS, including limited genetic counselling access, competing clinic priorities, absence of Canadian ECS recommendations, and added financial burdens for patients and clinics. While most participants supported using ECS in their clinics, varying opinions arose concerning its clinical utility and value. The culture within the realm of FHP was found to be moulded by their patient population, professional experiences, and educational backgrounds, all influencing FHP perceptions of ECS and its integration into practice. Participants suggested several recommendations and changes to address the discussed barriers and challenges, such as novel approaches to ECS pre-test counselling, enhancing access to genetic counselling, and genetic counsellors requiring physician support for implementing ECS improvements. In summary, this study illuminated the diverse landscape of practices and policies regarding ECS within fertility clinics, highlighting the intricate complexities surrounding ECS implementation in private fertility settings.
dc.description.noteFebruary 2024
dc.description.sponsorshipUniversity of Manitoba Graduate Fellowship and the Faculty of Graduate Studies Research Completion Scholarship.
dc.identifier.urihttp://hdl.handle.net/1993/37969
dc.language.isoeng
dc.rightsopen accessen_US
dc.subjectFertility
dc.subjectGenetic Counselling
dc.subjectAssisted Reproduction
dc.subjectQualitative
dc.subjectInfertility
dc.subjectCarrier Screening
dc.subjectIVF
dc.titleExploring the integration of expanded carrier screening within Canadian fertility clinics
dc.typemaster thesisen_US
local.subject.manitobano
oaire.awardNumber202112
oaire.awardTitleMaster's Award: Canada Graduate Scholarships
oaire.awardURIhttps://www.nserc-crsng.gc.ca/Students-Etudiants/PG-CS/CGSM-BESCM_eng.asp
project.funder.identifierhttps://doi.org/10.13039/501100000024
project.funder.nameCanadian Institutes of Health Research
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