Differential changes in beta-adrenoceptor signal transduction in left and right ventricles of infarcted rats

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dc.contributor.authorSethi, R
dc.contributor.authorSaini, HK
dc.contributor.authorWang, X
dc.contributor.authorElimban, V
dc.contributor.authorBabick, A
dc.contributor.authorDhalla, NS
dc.date.accessioned2007-10-05T15:50:26Z
dc.date.available2007-10-05T15:50:26Z
dc.date.issued2006-07-31
dc.description.abstractAlthough different experimental and clinical studies have revealed varying degrees of defects in beta-adrenoceptors (beta-ARs) during the development of heart failure, the mechanisms for differences in beta-AR signal transduction between the left (LV) and right ventricle (RV) are not understood. Because biochemical alterations in the myocardium depend on the stage of heart disease, this study was undertaken to assess the status of beta-ARs in the LV and RV at different stages of heart failure. Myocardial infarction was induced in rats by occluding the left coronary artery for 8 and 24 weeks. The beta-AR signal transduction was monitored by measuring beta(1)-AR density, the isoproterenol-induced positive inotropic effect, the increase in [Ca2+]i in cardiomyocytes, and the activation of adenylyl cyclase. The beta-AR signal transduction parameters in the 8- and 24-week failing LV were depressed, whereas the RV showed upregulation at 8 weeks and downregulation at 24 weeks of these mechanisms. These results suggest that beta-AR-mediated signal transduction in the LV and RV are differentially regulated and are dependent upon the stage of development of congestive heart failure due to myocardial infarction.en
dc.format.extent253835 bytes
dc.format.mimetypeapplication/pdf
dc.identifier.citation0008-4212; CAN J PHYSIOL PHARMACOL, JUL 2006, vol. 84, no. 7, p.747 to 754.en
dc.identifier.doi10.1139/Y05-150
dc.identifier.urihttp://hdl.handle.net/1993/2895
dc.language.isoengen_US
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dc.rightsopen accessen_US
dc.statusPeer revieweden
dc.subjectcardiac beta-adrenoceptorsen
dc.subjectcongestive heart failureen
dc.subjectcardiac hypertrophyen
dc.subjectmyocardial infarctionen
dc.subjectsignal transductionen
dc.subjectCONGESTIVE-HEART-FAILUREen
dc.subjectCARDIOMYOPATHIC UM-X7.1 HAMSTERSen
dc.subjectRENIN-ANGIOTENSIN SYSTEMen
dc.subjectMYOCARDIAL-INFARCTIONen
dc.subjectADENYLYL-CYCLASEen
dc.subjectVOLUME OVERLOADen
dc.subjectGENE-EXPRESSIONen
dc.subjectG-PROTEINSen
dc.subjectSYMPATHETIC ACTIVITYen
dc.subjectIMIDAPRIL TREATMENTen
dc.titleDifferential changes in beta-adrenoceptor signal transduction in left and right ventricles of infarcted ratsen
dc.typejournal articleen_US
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