Clozapine: a review of clinical practice guidelines and prescribing trends

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dc.contributor.authorWarnez, Stephanie
dc.contributor.authorAlessi-Severini, Silvia
dc.date.accessioned2014-04-25T11:06:52Z
dc.date.available2014-04-25T11:06:52Z
dc.date.issued2014-04-07
dc.date.updated2014-04-25T11:06:52Z
dc.description.abstractAbstract Background Clozapine effectiveness in the treatment of refractory schizophrenia has been sustained by published evidence in the last two decades, despite the introduction of safer options. Discussion Current clinical practice guidelines have strongly recommended the use of clozapine in treatment-resistant schizophrenia, but prescribing trends do not appear to have followed such recommendations. Clozapine is still underutilized especially in patients at risk of suicide. It seems that physicians are hesitant in prescribing clozapine due to concerns about serious adverse effects. Recent reports have highlighted the need to inform health professionals about the benefits of treating patients with clozapine and have voiced concerns about the underutilization of clozapine especially in patients at risk of suicide. Summary Guidelines and prescribing patterns reported in various countries worldwide are discussed. Suggestions on how to optimize clozapine utilization have been published but more efforts are needed to properly inform and support prescribers’ practices.
dc.description.versionPeer Reviewed
dc.identifier.citationBMC Psychiatry. 2014 Apr 07;14(1):102
dc.identifier.doihttp://dx.doi.org/10.1186/1471-244X-14-102
dc.identifier.urihttp://hdl.handle.net/1993/23558
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderStephanie Warnez et al.; licensee BioMed Central Ltd.
dc.titleClozapine: a review of clinical practice guidelines and prescribing trends
dc.typeJournal Article
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