World Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis

Simple item page
dc.contributor.authorSimons, F Estelle R
dc.contributor.authorArdusso, Ledit RF
dc.contributor.authorBilo, M Beatrice
dc.contributor.authorEl-Gamal, Yehia M
dc.contributor.authorLedford, Dennis K
dc.contributor.authorRing, Johannes
dc.contributor.authorSanchez-Borges, Mario
dc.contributor.authorSenna, Gian E
dc.contributor.authorSheikh, Aziz
dc.contributor.authorThong, Bernard Y
dc.contributor.authorthe World Allergy Organization
dc.date.accessioned2013-03-01T16:04:40Z
dc.date.available2013-03-01T16:04:40Z
dc.date.issued2011-02-15
dc.date.updated2013-03-01T16:04:40Z
dc.description.abstractAbstract The illustrated World Allergy Organization (WAO) Anaphylaxis Guidelines were created in response to absence of global guidelines for anaphylaxis. Uniquely, before they were developed, lack of worldwide availability of essentials for the diagnosis and treatment of anaphylaxis was documented. They incorporate contributions from more than 100 allergy/immunology specialists on 6 continents. Recommendations are based on the best evidence available, supported by references published to the end of December 2010. The Guidelines review patient risk factors for severe or fatal anaphylaxis, co-factors that amplify anaphylaxis, and anaphylaxis in vulnerable patients, including pregnant women, infants, the elderly, and those with cardiovascular disease. They focus on the supreme importance of making a prompt clinical diagnosis and on the basic initial treatment that is urgently needed and should be possible even in a low resource environment. This involves having a written emergency protocol and rehearsing it regularly; then, as soon as anaphylaxis is diagnosed, promptly and simultaneously calling for help, injecting epinephrine (adrenaline) intramuscularly, and placing the patient on the back or in a position of comfort with the lower extremities elevated. When indicated, additional critically important steps include administering supplemental oxygen and maintaining the airway, establishing intravenous access and giving fluid resuscitation, and initiating cardiopulmonary resuscitation with continuous chest compressions. Vital signs and cardiorespiratory status should be monitored frequently and regularly (preferably, continuously). The Guidelines briefly review management of anaphylaxis refractory to basic initial treatment. They also emphasize preparation of the patient for self-treatment of anaphylaxis recurrences in the community, confirmation of anaphylaxis triggers, and prevention of recurrences through trigger avoidance and immunomodulation. Novel strategies for dissemination and implementation are summarized. A global agenda for anaphylaxis research is proposed.
dc.description.versionPeer Reviewed
dc.identifier.citationWorld Allergy Organization Journal. 2011 Feb 15;4(2):13-37
dc.identifier.doihttp://dx.doi.org/10.1097/WOX.0b013e318211496c
dc.identifier.urihttp://hdl.handle.net/1993/16852
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderF Estelle R Simons et al.; licensee BioMed Central Ltd.
dc.titleWorld Allergy Organization Guidelines for the Assessment and Management of Anaphylaxis
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
1939-4551-4-2-13.xml
Size:
240.53 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
1939-4551-4-2-13.pdf
Size:
4.38 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works