Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants

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dc.contributor.authorMartinez, Stephanie E.
dc.contributor.authorSayre, Casey L.
dc.contributor.authorDavies, Neal M.
dc.date.accessioned2014-08-14T06:47:52Z
dc.date.available2014-08-14T06:47:52Z
dc.date.issued2013-4-16
dc.date.updated2014-08-14T06:47:53Z
dc.description.abstract3-Methoxypterostilbene is a naturally occurring stilbene with potential in the treatment of diabetes. The preclinical pharmacokinetics and pharmacodynamics of 3-methoxypterostilbene were evaluated in the present study. The right jugular veins of male Sprague-Dawley rats were cannulated. The rats were dosed 10 mg/kg or 100 mg/kg of 3-methoxypterostilbene intravenously (IV) or orally (PO), respectively. Serum and urine samples were analyzed using a previously validated reversed-phase HPLC method. Serum AUC, serum , urine , , and Vd for IV dosing were  μg/h/mL,  h,  h,  L/h/kg, and  L/kg, respectively (mean ± SEM, ) . Serum AUC, serum , urine , , and Vd for PO dosing were  μg/h/mL,  h,  h,  L/h/kg, and  L/kg, respectively (mean ± SEM, ). Bioavailability of the stilbene was determined to be 50.6%  ± 10.0%. A 3-methoxypterostilbene glucuronidated metabolite was detected in both serum and urine. 3-Methoxypterostilbene exhibited antidiabetic activity including -glucosidase and -amylase inhibition as well as concentration-dependent antioxidant capacity similar to resveratrol. 3-Methoxypterostilbene also exhibited anti-inflammatory activity. 3-Methoxypterostilbene appears to be a bioactive compound and may be useful in reducing postprandial hyperglycemia.
dc.description.versionPeer Reviewed
dc.identifier.citationStephanie E. Martinez, Casey L. Sayre, and Neal M. Davies, “Pharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants,” Evidence-Based Complementary and Alternative Medicine, vol. 2013, Article ID 261468, 11 pages, 2013. doi:10.1155/2013/261468
dc.identifier.doihttp://dx.doi.org/10.1155/2013/261468
dc.identifier.urihttp://hdl.handle.net/1993/23771
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2013 Stephanie E. Martinez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titlePharmacometrics of 3-Methoxypterostilbene: A Component of Traditional Chinese Medicinal Plants
dc.typeJournal Article
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