Evidence of Hepatitis B Virus Infection in Cancer and Noncancer Stem Cells Associated with Human Hepatocellular Carcinoma

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dc.contributor.authorMinuk, Gerald Y.
dc.contributor.authorBautista, Wendy
dc.contributor.authorKlein, Julianne
dc.date.accessioned2016-05-11T15:01:46Z
dc.date.available2016-05-11T15:01:46Z
dc.date.issued2016-3-29
dc.date.updated2016-05-08T09:32:01Z
dc.description.abstractBoth the hepatitis B virus (HBV) and cancer stem cells (CSCs) have been independently implicated in the pathogenesis of hepatocellular carcinoma (HCC). To date, there have been no reports describing HBV infection within CSCs. In this report we describe HBV core (HBcAg) and HBx protein expression within CSCs associated with human HCC. HBV markers were also identified in nonmalignant stem cells present in adjacent nontumor tissue. These findings provide new insights into the pathogenesis of HBV-induced HCC and are potentially relevant to the treatment of both HCC and chronic HBV.
dc.description.versionPeer Reviewed
dc.identifier.citationGerald Y. Minuk, Wendy Bautista, and Julianne Klein, “Evidence of Hepatitis B Virus Infection in Cancer and Noncancer Stem Cells Associated with Human Hepatocellular Carcinoma,” Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 2016, Article ID 8931591, 4 pages, 2016. doi:10.1155/2016/8931591
dc.identifier.urihttp://dx.doi.org/10.1155/2016/8931591
dc.identifier.urihttp://hdl.handle.net/1993/31291
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2016 Gerald Y. Minuk et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleEvidence of Hepatitis B Virus Infection in Cancer and Noncancer Stem Cells Associated with Human Hepatocellular Carcinoma
dc.typeJournal Article
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