Single wall carbon nanotube based nanoparticles and hydrogel for cancer therapy

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dc.contributor.authorLiu, Shuhan Jr
dc.contributor.examiningcommitteeKong, Jiming (Human Anatomy and Cell Science) Ko, Alex (National Research Council Canada)en_US
dc.contributor.supervisorZhong, Wen (Textile Sciences) Xing, Malcolm (Mechanical Engineering)en_US
dc.date.accessioned2014-01-10T20:41:00Z
dc.date.available2014-01-10T20:41:00Z
dc.date.issued2014en_US
dc.degree.disciplineTextile Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractNowadays, cancer treatment and tissue regeneration have attracted large amount of attention. Single Wall Carbon Nanotubes (SWNT) possess large surface area and outstanding optical and electrical performance, making it a promising component in cancer therapy and tissue reengineering systems. In this study, four disease treating systems based on SWNT are developed. They are pH-sensitive poly(ethylene glycol)-doxorubicin(PEG-DOX)@SWNT drug release system, temperature sensitive SWNT hydrogel, SWNT based biocompatible magnetic hydrogel and biocompatible SWNT-gelatin-F127-cysteamine hydrogel for tissue engineering. The successfully synthesized target compounds are characterized by FTIR. The in vitro release of drugs from the drug release systems is evaluated upon changes of pH values and the laser scanning. The effect of cancer treatment systems on specific kind of cells are examined by confocal laser scanning microscopy (CLSM). The results indicate that all of the four systems show great potential in the biomedical applications especially in disease therapy applications.en_US
dc.description.noteFebruary 2014en_US
dc.identifier.citationLiu, S., et al., NIR initiated and pH sensitive single-wall carbon nanotubes for doxorubicin intracellular delivery. Journal of Materials Chemistry B, 2014: p. DOI: 10.1039/C3TB21362E.en_US
dc.identifier.urihttp://hdl.handle.net/1993/23149
dc.language.isoengen_US
dc.publisherJournal of Materials Chemistry Ben_US
dc.rightsopen accessen_US
dc.subjectSingle wall carbon nanotubesen_US
dc.subjecthydrogelen_US
dc.subjectpoly(ethylene glycol)en_US
dc.subjectcancer therapyen_US
dc.titleSingle wall carbon nanotube based nanoparticles and hydrogel for cancer therapyen_US
dc.typemaster thesisen_US
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