The effect of lentils (Lens culinaris) on hypertension and hypertension–associated vascular remodeling in the spontaneously hypertensive rat

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dc.contributor.authorHanson, Matthew G.
dc.contributor.examiningcommitteeAnderson, Hope (Pharmacy) Netticadan, Thomas (Physiology) Pierce, Grant (Physiology)en_US
dc.contributor.supervisorZahradka, Peter (Physiology) Taylor, Carla (Human Nutritional Sciences)en_US
dc.date.accessioned2013-09-09T16:54:08Z
dc.date.available2013-09-09T16:54:08Z
dc.date.issued2013en_US
dc.degree.disciplinePhysiologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractConsumption of pulse crops has been linked to improvements in blood vessel function, but which pulse variety/type is better and how they work remains unknown. Two distinct studies were conducted to address these questions. In study 1, spontaneously hypertensive rats (SHR) were fed control diet, or diets containing 30% (w/w) beans, peas, lentils, chickpeas, or mixed pulses. Normotensive Wistar-Kyoto (WKY) rats were fed the control diet. The lentil–containing diet significantly attenuated the rise in BP (+8 and +31 mmHg, vs. control) and reduced large artery remodeling compared to control. In study 2, SHR were fed control, mixed lentil, green lentil, or red lentil diets for 8 weeks. WKY were fed control or mixed lentil diets. Green lentils decreased arterial remodeling and improved arterial compliance in the SHR. A diet high in green lentils could be a valuable adjunct to allopathic medicine to mitigate effects of hypertension on the vasculature.en_US
dc.description.noteOctober 2013en_US
dc.identifier.citationBritish Journal of Nutritionen_US
dc.identifier.urihttp://hdl.handle.net/1993/22140
dc.language.isoengen_US
dc.publisherCambridge University Pressen_US
dc.rightsopen accessen_US
dc.subjecthypertensionen_US
dc.subjectlentilsen_US
dc.titleThe effect of lentils (Lens culinaris) on hypertension and hypertension–associated vascular remodeling in the spontaneously hypertensive raten_US
dc.typemaster thesisen_US
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