Prognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study

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dc.contributor.authorGomez, Alwyn
dc.contributor.authorFroese, Logan
dc.contributor.authorGriesdale, Donald
dc.contributor.authorThelin, Eric P.
dc.contributor.authorRaj, Rahul
dc.contributor.authorvan Iperenburg, Levi
dc.contributor.authorTas, Jeanette
dc.contributor.authorAries, Marcel
dc.contributor.authorStein, Kevin Y.
dc.contributor.authorGallagher, Clare
dc.contributor.authorBernard, Francis
dc.contributor.authorKramer, Andreas H.
dc.contributor.authorZeiler, Frederick A.
dc.date.accessioned2024-04-01T16:45:33Z
dc.date.available2024-04-01T16:45:33Z
dc.date.issued2024-03-14
dc.date.updated2024-04-01T06:26:48Z
dc.description.abstractBackground Near-infrared spectroscopy regional cerebral oxygen saturation (rSO2) has gained interest as a raw parameter and as a basis for measuring cerebrovascular reactivity (CVR) due to its noninvasive nature and high spatial resolution. However, the prognostic utility of these parameters has not yet been determined. This study aimed to identify threshold values of rSO2 and rSO2-based CVR at which outcomes worsened following traumatic brain injury (TBI). Methods A retrospective multi-institutional cohort study was performed. The cohort included TBI patients treated in four adult intensive care units (ICU). The cerebral oxygen indices, COx (using rSO2 and cerebral perfusion pressure) as well as COx_a (using rSO2 and arterial blood pressure) were calculated for each patient. Grand mean thresholds along with exposure-based thresholds were determined utilizing sequential chi-squared analysis and univariate logistic regression, respectively. Results In the cohort of 129 patients, there was no identifiable threshold for raw rSO2 at which outcomes were found to worsen. For both COx and COx_a, an optimal grand mean threshold value of 0.2 was identified for both survival and favorable outcomes, while percent time above − 0.05 was uniformly found to have the best discriminative value. Conclusions In this multi-institutional cohort study, raw rSO2was found to contain no significant prognostic information. However, rSO2-based indices of CVR, COx and COx_a, were found to have a uniform grand mean threshold of 0.2 and exposure-based threshold of − 0.05, above which clinical outcomes markedly worsened. This study lays the groundwork to transition to less invasive means of continuously measuring CVR.
dc.identifier.citationCritical Care. 2024 Mar 14;28(1):78
dc.identifier.doi10.1186/s13054-024-04859-6
dc.identifier.urihttp://hdl.handle.net/1993/38119
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.subjectCerebrovascular reactivity
dc.subjectMultimodal monitoring
dc.subjectNear-infrared spectroscopy
dc.subjectTraumatic brain injury
dc.titlePrognostic value of near-infrared spectroscopy regional oxygen saturation and cerebrovascular reactivity index in acute traumatic neural injury: a CAnadian High-Resolution Traumatic Brain Injury (CAHR-TBI) Cohort Study
dc.typeJournal Article
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Human Anatomy and Cell Science
oaire.citation.issue78
oaire.citation.titleCritical Care
oaire.citation.volume28
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