Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin
| dc.contributor.author | Murali, Megha | |
| dc.contributor.examiningcommittee | Nachtigal, Mark (Biochemistry and Medical Genetics) Taylor, Carla (Human Nutritional Sciences) Zahradka, Peter (Physiology and Pathophysiology). | en_US |
| dc.contributor.supervisor | Wigle, Jeffrey (Biochemistry and Medical Genetics) | en_US |
| dc.date.accessioned | 2016-09-16T14:03:53Z | |
| dc.date.available | 2016-09-16T14:03:53Z | |
| dc.date.issued | 2016 | |
| dc.degree.discipline | Biochemistry and Medical Genetics | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Adiponectin is an abundant hormone secreted by adipocytes that exhibits anti-diabetic, anti-inflammatory and anti-atherogenic properties. However, in obesity, as adipocytes enlarge, adiponectin secretion declines. A sex dimorphism is observed in adiponectin levels with women having higher levels than men. We hypothesized that a lack of adiponectin negatively affects both insulin sensitivity and adipose physiology in a sex-dependent manner. In this study, male and female adiponectin knockout or wild-type mice were fed with either a low fat or high fat diet. Male knockout animals were more glucose intolerant and had elevated fasting glucose levels. In contrast, both adiponectin knockout and wild-type females showed decreased hepatic lipid accumulation on a high fat diet. In both sexes, lean adiponectin knockout mice had significantly smaller fat depot weights and lesser hepatic lipid accumulation than the lean wild-type mice. However, on high fat diet, only male adiponectin knockout mice had fat depot weights that were comparable to wild-type mice, which indicate a novel sex-specific role of adiponectin in determining adiposity. | en_US |
| dc.description.note | October 2016 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/31788 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Adiponectin | en_US |
| dc.title | Elucidating the effect of sex on the metabolic and vascular perturbations induced by the absence of adiponectin | en_US |
| dc.type | master thesis | en_US |