Extramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia

Simple item page
dc.contributor.authorBowen, Joslin M.
dc.contributor.authorPerry, Anamarija M.
dc.contributor.authorQuist, Erin
dc.contributor.authorAkhtari, Mojtaba
dc.date.accessioned2015-05-14T15:31:56Z
dc.date.available2015-05-14T15:31:56Z
dc.date.issued2015-4-16
dc.date.updated2015-04-18T07:01:27Z
dc.description.abstractChronic myelomonocytic leukemia (CMML) is a clonal hematopoietic malignancy with features of both a myeloproliferative neoplasm and a myelodysplastic syndrome. Even though extramedullary leukemic infiltration is common in CMML patients, lymph node involvement has rarely been reported in the literature. We present an unusual case of a 72-year-old female who was found to have extramedullary hematopoiesis (EMH) in a sentinel lymph node that was excised during mastectomy for lobular breast carcinoma. One year later bone marrow biopsy was performed due to persistent anemia, thrombocytopenia, and monocytosis and the patient was diagnosed with CMML. Our case illustrates the importance of recognizing EMH in a lymph node during routine histological examination, especially in adults. Proliferation of bone marrow elements in a lymph node, in a patient with no known hematologic disorder, should trigger immediate bone marrow evaluation, as this could be the first clue in diagnosing underlying bone marrow disorder.
dc.description.versionPeer Reviewed
dc.identifier.citationJoslin M. Bowen, Anamarija M. Perry, Erin Quist, and Mojtaba Akhtari, “Extramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia,” Case Reports in Pathology, vol. 2015, Article ID 594970, 4 pages, 2015. doi:10.1155/2015/594970
dc.identifier.urihttp://dx.doi.org/10.1155/2015/594970
dc.identifier.urihttp://hdl.handle.net/1993/30445
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 Joslin M. Bowen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleExtramedullary Hematopoiesis in a Sentinel Lymph Node as an Early Sign of Chronic Myelomonocytic Leukemia
dc.typeJournal Article
Files
Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
CRIPA.2015.594970.xml
Size:
6.82 KB
Format:
Extensible Markup Language
Description:
Download
Thumbnail Image
Name:
CRIPA.2015.594970.pdf
Size:
4.56 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.27 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works