Beneficial Effects of Germinated Brown Rice on Cardiovascular Risk Factors in LDL Receptor Knockout Mice
| dc.contributor.author | Ghazzawi, Nora | |
| dc.contributor.examiningcommittee | Eskin, Michael (Human Nutritional Sciences)) Beta, Trust (Food Science) | en_US |
| dc.contributor.supervisor | Moghadasian, Mohammed (Human Nutritional Sciences) Shen, Garry (Internal Medicin) | en_US |
| dc.date.accessioned | 2017-04-11T14:50:39Z | |
| dc.date.available | 2017-04-11T14:50:39Z | |
| dc.date.issued | 2017 | |
| dc.degree.discipline | Human Nutritional Sciences | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Based on accumulating evidence, adequate intake of whole grains is associated with reduced cardiovascular disease CVD risk. Germinated brown rice (GBR) has been used in East Asian countries as an alternative grain. Preliminary studies suggest GBR has potential health benefits, including reducing CVD risk, but the mechanism remains unclear. The hypothesis of the project is that long-term consumption of GBR would reduce atherogenic risk factors in low-density lipoprotein receptor knockout (LDLr-KO) mice. To test the hypothesis, three groups of male LDLr-KO mice were fed with one of the following diets for 24 weeks: (a) commercial mouse chow, used as the control diet; (b) chow was replaced with 60% (w/w) Chinese white rice (CWR); and (c) chow was replaced with 60% (w/w) GBR. All diets were supplemented with 0.06% (w/w) dietary cholesterol to accelerate atherogenesis. Blood samples, hearts, livers and feces were collected and used for biochemical and histological analyses. The results demonstrated that no significant difference was detected in body weights, plasma or fecal lipid profiles and antioxidant enzyme activities among groups. However, GBR consumption significantly decreased atherosclerotic lesion (P = 0.003) in the aortic roots as compared with that in the CWR group, but there was no significant difference as compared with that in the control group (P = 0.4). In addition, GBR significantly decreased monocyte adhesion to the aorta in LDLr-KO mice as compared to that in the CWR group (P=0.0001), but not with the control group. These data suggested that GBR may be beneficial for the prevention of vascular inflammation and atherogenesis in LDLr-KO mice. Additional studies in animal models and humans may further investigate the mechanisms of the beneficial effects of GBR on vascular inflammation and atherogenesis. | en_US |
| dc.description.note | May 2017 | en_US |
| dc.identifier.citation | APA | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32204 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Cardiovascular disease, Germinated brown rice, LDL-r KO mice | en_US |
| dc.title | Beneficial Effects of Germinated Brown Rice on Cardiovascular Risk Factors in LDL Receptor Knockout Mice | en_US |
| dc.type | master thesis | en_US |