Longitudinal Change in BMD in a Population Based Cohort of Patients with Inflammatory Bowel Disease

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dc.contributor.authorTargownik, Laura
dc.contributor.authorLeslie, William
dc.contributor.authorCarr, Rachel
dc.contributor.authorClara, Ian
dc.contributor.authorMiller, Norine
dc.contributor.authorRogala, Linda
dc.contributor.authorGraff, Lesley A.
dc.contributor.authorWalker, John
dc.contributor.authorBernstein, Charles N.
dc.date.accessioned2015-05-11T17:50:05Z
dc.date.available2015-05-11T17:50:05Z
dc.date.issued2012-11
dc.description.abstractPersons with inflammatory bowel disease (IBD) are reported to have a high prevalence of osteoporosis and reduced bone mineral density (BMD) and to be at higher risk of fracture. The course of BMD loss over time is poorly characterized in persons with IBD. Eighty-six persons, stratified by age, were enrolled from a population-based longitudinal IBD cohort study to undergo BMD testing at baseline, with final BMD testing a mean of 4.3 years later. The proportion of subjects with significant change in BMD at the lumbar spine, total hip, and femoral neck was assessed, as were clinical, biochemical, and anthropomorphic changes. Vertebral radiographs were also obtained at baseline and at the end of follow-up in those aged 50 years and above to detect vertebral fractures. The change in BMD seen in this cohort of IBD patients was similar to the expected rate of BMD loss in the general population. Age >50 years, decreasing body mass index (BMI), and corticosteroid use were most notably correlated with BMD loss. Subjects aged <50 years did not have statistically significant declines in BMD. IBD symptom activity scores correlated poorly with BMD loss. Vertebral fractures were uncommon, with only two subjects out of 41 >50 years old developing a definite radiographic fracture over the course of follow-up. No major nonvertebral fractures were observed. Patients with IBD do not appear to have significantly accelerated BMD loss. Older age, decreasing BMI, and corticosteroid use may identify IBD patients at greater risk for BMD loss.en_US
dc.identifier.citationCalcif Tissue Int. 2012 Nov;91(5):356-63en_US
dc.identifier.doi10.1007/s00223-012-9650-1
dc.identifier.urihttp://hdl.handle.net/1993/30424
dc.language.isoengen_US
dc.publisherCalcified Tissue Internationalen_US
dc.relation.ispartofseries91(5);356-63
dc.rightsopen accessen_US
dc.subjectBMDen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.subjectCohorten_US
dc.subjectPopulationen_US
dc.subjectBernsteinen_US
dc.titleLongitudinal Change in BMD in a Population Based Cohort of Patients with Inflammatory Bowel Diseaseen_US
dc.typeArticleen_US
dc.typeDataseten_US
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