Natural killer cell function in chronic HCV infection

Simple item page
dc.contributor.authorCollister, Mark
dc.contributor.examiningcommitteeKung, Sam (Immunology) Carpenter, Michael (Medical Microbiology)en_US
dc.contributor.supervisorRempel, Julia (Immunology)en_US
dc.date.accessioned2013-08-21T14:29:12Z
dc.date.available2013-08-21T14:29:12Z
dc.date.issued2013-08-21
dc.degree.disciplineImmunologyen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractNK cells control viral replication through cytotoxicity and IFNγ production. These functions were assessed in chronic HCV infected patients undergoing treatment. Aboriginals have genetic polymorphisms that may enhance NK cell function suggesting more effective clearance of chronic HCV than Caucasians. NK cell function was similar at baseline between ethnicities. At 3 months of treatment, Caucasian had higher NK killing potential compared to Aboriginal patients. This had no effect on treatment outcomes. NK cell cytotoxicity negatively correlated with viral loads while NK IFNγ production, particularly within the CD56bright subset, positively correlated with viral load suggesting that viral loads control NK cells function through an unknown mechanism. NK cell killing reflect fibrosis, but not liver damage measured by liver enzymes. IFNγ production,by NK cells does not reflect fibrosis nor liver enzymes levels. Lastly, NK cell function does not associate with therapeutic outcomes of chronic HCV infection suggesting that they do not directly play a role in therapeutic clearance of HCV.en_US
dc.description.noteOctober 2013en_US
dc.identifier.urihttp://hdl.handle.net/1993/22047
dc.language.isoengen_US
dc.rightsopen accessen_US
dc.subjectNKen_US
dc.subjectHCVen_US
dc.subjectCytotoxicityen_US
dc.subjectIFNγen_US
dc.titleNatural killer cell function in chronic HCV infectionen_US
dc.typemaster thesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Collister_Mark.pdf
Size:
1.36 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.25 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
FGS - Electronic Theses and Practica