The effects of consumption of functional foods consisting of high oleic canola oil, docosahexaenoic acid and barley β-glucan on plasma lipids
| dc.contributor.author | Abraham, Anjalika | |
| dc.contributor.examiningcommittee | Ames, Nancy (Human Nutrition Science) Thandapilly, Sijo (Human Nutrition Science) Scanlon, Martin (Food Science) | en_US |
| dc.contributor.supervisor | Jones, Peter (Human Nutrition Science) | en_US |
| dc.date.accessioned | 2017-10-05T18:55:00Z | |
| dc.date.available | 2017-10-05T18:55:00Z | |
| dc.date.issued | 2017 | |
| dc.degree.discipline | Human Nutritional Sciences | en_US |
| dc.degree.level | Master of Science (M.Sc.) | en_US |
| dc.description.abstract | Functional foods containing high oleic canola oil, omega-3 oils and barley β-glucan have been individually shown to improve blood lipid profiles. However, this is the first study to test the intake of a combination of these ingredients incorporated into a single food product in a human trial. The objective was to test the synergistic impact of consuming a combination of novel foods containing one or more functional ingredient on blood lipid profile and the Framingham risk score. The secondary objective was to predict the mechanism of action of the cholesterol lowering effected by these ingredients. A randomized single-blinded free-living crossover study design was used. This study consisted of thirty-five participants, consisting of four intervention phases of four weeks each. Each phase was separated by a four-week washout period. The participants were randomly assigned to treatments which consisted of one test muffin and two test cookies per day. At endpoint, the high oleic canola docosahexaenoic acid treatment showed a significant increase (P< 0.05) in high-density lipoprotein levels (HDL-C) and a significant decrease (P< 0.05) in triglyceride levels (TG) when compared to control. We also observed a significant decrease (P< 0.05) in very low-density lipoprotein levels (VLDL-C), total cholesterol to high-density lipoprotein ratio (TC: HDL-C) and diastolic blood pressure (DBP) when compared to the control. The combination of high oleic canola oil, omega-3 oils and barley β-glucan showed a significant increase (P< 0.05) in high-density lipoprotein levels (HDL-C) and a significant decrease (P< 0.05) in triglyceride levels (TG) (P< 0.05) when compared to control. We also observed a significant decrease (P< 0.05) in very low-density lipoprotein levels (VLDL-C), total cholesterol to high-density lipoprotein ratio (TC: HDL-C) and diastolic blood pressure (DBP) at endpoint when compared to the control. No significant differences were observed for total cholesterol (TC) (P< 0.05), low-density lipoprotein level (LDL-C) (P< 0.05), glucose level and systolic blood pressure (SBP) (P< 0.05). At endpoint when comparing the combined high oleic canola docosahexaenoic acid and high molecular weight barley β-glucan treatment to control the Framingham risk score, decreased (P< 0.05) for both males and females. For the non-cholesterol sterols the high oleic canola docosahexaenoic acid treatment showed a significant increase (P< 0.05) in sitosterol when compared to control. The combination of high oleic canola oil, omega-3 oils and barley β-glucan showed a significant increase (P< 0.05) in sitosterol when compared to control. However the findings showed no change in cholesterol synthesis. We conclude that when compared to their individual treatments alone the combination of high oleic canola oil, omega-3 oil and barley β-glucan as a single food product do have additional positive outcomes on blood lipid profiles and the Framingham risk score. | en_US |
| dc.description.note | February 2018 | en_US |
| dc.identifier.uri | http://hdl.handle.net/1993/32662 | |
| dc.language.iso | eng | en_US |
| dc.rights | open access | en_US |
| dc.subject | Keywords: high oleic canola oil, barley β-glucan, DHA, cholesterol, blood lipid profiles. | en_US |
| dc.title | The effects of consumption of functional foods consisting of high oleic canola oil, docosahexaenoic acid and barley β-glucan on plasma lipids | en_US |
| dc.type | master thesis | en_US |