Divergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition

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dc.contributor.authorMercer, Emily M.
dc.contributor.authorRamay, Hena R.
dc.contributor.authorMoossavi, Shirin
dc.contributor.authorLaforest-Lapointe, Isabelle
dc.contributor.authorReyna, Myrtha E.
dc.contributor.authorBecker, Allan B.
dc.contributor.authorSimons, Elinor
dc.contributor.authorMandhane, Piush J.
dc.contributor.authorTurvey, Stuart E.
dc.contributor.authorMoraes, Theo J.
dc.contributor.authorSears, Malcolm R.
dc.contributor.authorSubbarao, Padmaja
dc.contributor.authorAzad, Meghan B.
dc.contributor.authorArrieta, Marie-Claire
dc.date.accessioned2024-03-06T15:19:32Z
dc.date.available2024-03-06T15:19:32Z
dc.date.issued2024-02-07
dc.date.updated2024-03-01T04:36:41Z
dc.description.abstractBackground The gut microbiome undergoes primary ecological succession over the course of early life before achieving ecosystem stability around 3 years of age. These maturational patterns have been well-characterized for bacteria, but limited descriptions exist for other microbiota members, such as fungi. Further, our current understanding of the prevalence of different patterns of bacterial and fungal microbiome maturation and how inter-kingdom dynamics influence early-life microbiome establishment is limited. Results We examined individual shifts in bacterial and fungal alpha diversity from 3 to 12 months of age in 100 infants from the CHILD Cohort Study. We identified divergent patterns of gut bacterial or fungal microbiome maturation in over 40% of infants, which were characterized by differences in community composition, inter-kingdom dynamics, and microbe-derived metabolites in urine, suggestive of alterations in the timing of ecosystem transitions. Known microbiome-modifying factors, such as formula feeding and delivery by C-section, were associated with atypical bacterial, but not fungal, microbiome maturation patterns. Instead, fungal microbiome maturation was influenced by prenatal exposure to artificially sweetened beverages and the bacterial microbiome, emphasizing the importance of inter-kingdom dynamics in early-life colonization patterns. Conclusions These findings highlight the ecological and environmental factors underlying atypical patterns of microbiome maturation in infants, and the need to incorporate multi-kingdom and individual-level perspectives in microbiome research to improve our understandings of gut microbiome maturation patterns in early life and how they relate to host health. Video Abstract
dc.identifier.citationMicrobiome. 2024 Feb 07;12(1):22
dc.identifier.doi10.1186/s40168-023-01735-3
dc.identifier.urihttp://hdl.handle.net/1993/38037
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.subjectGut microbiome
dc.subjectGut mycobiome
dc.subjectAlpha diversity
dc.subjectEarly life
dc.subjectMicrobial succession
dc.subjectMicrobiome maturation
dc.subjectColonization patterns
dc.subjectInter‑kingdom dynamics
dc.subjectGut fungi
dc.titleDivergent maturational patterns of the infant bacterial and fungal gut microbiome in the first year of life are associated with inter-kingdom community dynamics and infant nutrition
dc.typeJournal Article
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Pediatrics and Child Health
oaire.citation.issue22
oaire.citation.titleMicrobiome
oaire.citation.volume12
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