Relapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B

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dc.contributor.authorMcQuarrie, Shauna
dc.contributor.authorKasper, Ken
dc.contributor.authorMoffatt, Dana C
dc.contributor.authorMarko, Daniel
dc.contributor.authorKeynan, Yoav
dc.date.accessioned2016-06-06T17:01:32Z
dc.date.available2016-06-06T17:01:32Z
dc.date.issued2015-1-1
dc.date.updated2016-06-05T09:40:59Z
dc.description.abstractThe present report documents a 49-year-old HIV-infected man receiving antiretroviral therapy with a suboptimal immune response and a CD4 count of 95 cells/mm3, despite virological suppression. Investigation of bone marrow was conducted and yielded a diagnosis of visceral leishmaniasis. The clinical course was complicated by gastrointestinal involvment and relapse occurred after amphotericin B therapy. With the addition of miltefosine, the patient no longer presented with bone marrow amastigotes, and displayed an increased CD4 count and negative Leishmania polymerase chain reaction results. The present case highlights atypical presentation of visceral leishmaniasis, including poor immune reconstitution and gastrointestinal involvement. The high likelihood of relapse and response to combination therapy are illustrated.
dc.description.versionPeer Reviewed
dc.identifier.citationShauna McQuarrie, Ken Kasper, Dana C Moffatt, Daniel Marko, and Yoav Keynan, “Relapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B,” Canadian Journal of Infectious Diseases and Medical Microbiology, vol. 26, no. 6, pp. 325-329, 2015. doi:10.1155/2015/176545
dc.identifier.urihttp://dx.doi.org/10.1155/2015/176545
dc.identifier.urihttp://hdl.handle.net/1993/31314
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2015 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleRelapse of Visceral Leishmaniasis in an HIV-Infected Patient Successfully Treated with a Combination of Miltefosine and Amphotericin B
dc.typeJournal Article
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