Armstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure

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dc.contributor.authorCaron, Laurence
dc.contributor.authorDelisle, Jean-Sébastien
dc.contributor.authorStrong, James E.
dc.contributor.authorDeschambault, Yvon
dc.contributor.authorLombard-Vadnais, Félix
dc.contributor.authorLabbé, Annie-Claude
dc.contributor.authorLesage, Sylvie
dc.date.accessioned2024-01-03T22:07:25Z
dc.date.available2024-01-03T22:07:25Z
dc.date.issued2023-12-12
dc.date.updated2024-01-01T08:11:02Z
dc.description.abstractBackground Lymphocytic choriomeningitis virus (LCMV) is a human pathogen naturally present in wild rodents. In addition, LCMV is routinely used in immunology research as a model of viral infection in mice. The Armstrong common laboratory strain and the Clone-13 variant induce acute and chronic infections in mice, respectively. The frequent use of this virus in laboratory settings is associated with a risk of human infection for laboratory personnel. In contrast to LCMV Clone-13, few human laboratory infections with LCMV Armstrong have been reported, leading to a poor understanding of symptoms related to infection with this specific LCMV strain. Case presentation A researcher accidentally infected herself percutaneously with LCMV Armstrong. Symptoms including headaches, dizziness, eye pain and nausea appeared seven days post-exposure and lasted ten days. LCMV-IgM antibodies were detected at 28 days post-infection and IgG seroconversion was observed later. Complete recovery was confirmed three months post exposure. Conclusions Research involving live viruses comes with the risk of infection for research personnel. This case is the first reported accidental human infection with LCMV Armstrong. The symptoms differed from reported infections with LCMV Clone-13, by the absence of fever and vomiting, and presence of leg numbness. This report will therefore help clinicians and public health authorities to recognize the symptoms associated with LCMV Armstrong infections and to offer appropriate counselling to individuals who accidentally expose themselves.
dc.identifier.citationVirology Journal. 2023 Dec 12;20(1):294
dc.identifier.doi10.1186/s12985-023-02258-x
dc.identifier.urihttp://hdl.handle.net/1993/37905
dc.language.isoeng
dc.language.rfc3066en
dc.publisherBMC
dc.rightsopen accessen_US
dc.rights.holderThe Author(s)
dc.subjectLymphocytic choriomeningitis virus (LCMV)
dc.subjectArmstrong strain
dc.subjectLaboratory accidental exposure
dc.titleArmstrong strain lymphocytic choriomeningitis virus infection after accidental laboratory exposure
dc.typeJournal Article
local.author.affiliationRady Faculty of Health Sciences::Max Rady College of Medicine::Department of Medical Microbiology and Infectious Diseases
oaire.citation.titleVirology Journal
oaire.citation.volume20
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