Effect of dietary polyunsaturated fatty acids on rat tissue oxylipin profiles

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dc.contributor.authorShan, Leng
dc.contributor.examiningcommitteeSuh, Miyoung (Human Nutritional Sciences) Hatch, Grant (Pharmacology and Therapeutics & Biochemistry and Medical Genetics)en_US
dc.contributor.supervisorAukema, Harold (Human Nutritional Sciences)en_US
dc.date.accessioned2017-01-25T19:38:51Z
dc.date.available2017-01-25T19:38:51Z
dc.date.issued2015-09en_US
dc.degree.disciplineHuman Nutritional Sciencesen_US
dc.degree.levelMaster of Science (M.Sc.)en_US
dc.description.abstractThere is much information on the effects of dietary lipids on tissue fatty acid composition, but little data on their bioactive lipid metabolites that mediate their effects on health and disease. Therefore diets differing in levels of linoleic (LA), α-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were provided to male and female weanling rats for 6 weeks, and fatty acids and their oxygenated metabolites (oxylipins) were quantified in kidney, liver and serum. The findings reveal that although oxylipin profiles are generally similar to fatty acid profiles there are some notable exceptions: dietary LA can increase LA and arachidonic acid derived oxylipins without changing the precursor fatty acid level; dietary ALA can increase DHA oxylipins without changing DHA levels. Male tissues generally had higher levels of oxylipins than females, with a few exceptions (e.g. F-series prostaglandins). These findings have implications for dietary recommendations for LA and n-3 fatty acids.en_US
dc.description.noteFebruary 2017en_US
dc.identifier.citationJournal of Nutritionen_US
dc.identifier.urihttp://hdl.handle.net/1993/32073
dc.language.isoengen_US
dc.publisherGabbs M, Leng S, Devassy JG, Monirujjaman M, Aukema HMen_US
dc.rightsopen accessen_US
dc.subjectOxylipin, Fatty acid, Polyunsaturated Fatty Acid, Lipid mediator, Prostagladins, Cyclooxygenase, Cytochrome P450, Lipoxygenase, LA, ALA, EPA, DHAen_US
dc.titleEffect of dietary polyunsaturated fatty acids on rat tissue oxylipin profilesen_US
dc.typemaster thesisen_US
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