The age factor in survival of a population cohort of well-differentiated thyroid cancer

Simple item page
dc.contributor.authorMazurat, Andrea
dc.contributor.authorTorroni, Andrea
dc.contributor.authorHendrickson-Rebizant, Jane
dc.contributor.authorBenning, Harbinder
dc.contributor.authorNason, Richard W.
dc.contributor.authorPathak, K. Alok
dc.date.accessioned2014-06-25T19:33:34Z
dc.date.available2014-06-25T19:33:34Z
dc.date.issued2013-09-21
dc.description.abstractWell-differentiated thyroid carcinoma (WDTC) represents a group of thyroid cancers with excellent prognosis. Age, a well-recognized risk factor for WDTC, has been consistently included in various prognostic scoring systems. An age threshold of 45 years is currently used by the American Joint Cancer Committee-TNM staging system for the risk stratification of patients. This study analyzes the relationship between the patients' age at diagnosis and thyroid cancer-specific survival in a population-based thyroid cancer cohort of 2115 consecutive patients with WDTC, diagnosed during 1970–2010, and evaluates the appropriateness of the currently used age threshold. Oncological outcomes of patients in terms of disease-specific survival (DSS) and disease-free survival (DFS) were calculated by the Kaplan–Meier method, while multivariable analysis was done by the Cox proportional hazard model and proportional hazards regression for sub-distribution of competing risks to assess the independent influence of various prognostic factors. The mean age of the patients was 47.3 years, 76.6% were female and 83.3% had papillary carcinoma. The median follow-up of the cohort was 122.4 months. The DSS and DFS were 95.4 and 92.8% at 10 years and 90.1 and 87.6% at 20 years, respectively. Multivariable analyses confirmed patient's age to be an independent risk factor adversely affecting the DSS but not the DFS. Distant metastasis, incomplete surgical resection, T3/T4 stages, Hürthle cell histology, and male gender were other independent prognostic determinants. The DSS was not independently influenced by age until the age of 55 years. An age threshold of 55 years is better than that of 45 years for risk stratification.en_US
dc.description.sponsorshipThis study was supported by the University of Manitoba Research Grant 2009 and the Department of Surgery, University of Manitoba Research Grant 2010.en_US
dc.identifier.citationMazurat, A., Torroni, A., Hendrickson-Rebizant, J., et al. The age factor in survival of a population cohort of well-differentiated thyroid cancer. Endocrine Connections, 2(3), 154-160.en_US
dc.identifier.doihttp://dx.doi.org/10.1530/EC-13-0056
dc.identifier.urihttp://hdl.handle.net/1993/23656
dc.language.isoengen_US
dc.publisherBioscientificaen_US
dc.rightsopen accessen_US
dc.subjectRisk stratificationen_US
dc.subjectThyroid carcinomaen_US
dc.subjectPrognosisen_US
dc.subjectSurvivalen_US
dc.subjectOutcomeen_US
dc.titleThe age factor in survival of a population cohort of well-differentiated thyroid canceren_US
dc.typeArticleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Mazurat et al.pdf
Size:
159.25 KB
Format:
Adobe Portable Document Format
Description:
Main article
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.17 KB
Format:
Item-specific license agreed to upon submission
Description:
Download
Collections
University of Manitoba Scholarship
Rady Faculty of Health Sciences Scholarly Works