Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)

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dc.contributor.authorChow, Benjamin JW
dc.contributor.authorGreen, Rachel E
dc.contributor.authorCoyle, Doug
dc.contributor.authorLaine, Mika
dc.contributor.authorHanninen, Helena
dc.contributor.authorLeskinen, Hanna
dc.contributor.authorRajda, Miroslav
dc.contributor.authorLarose, Eric
dc.contributor.authorHartikainen, Juha
dc.contributor.authorHedman, Marja
dc.contributor.authorMielniczuk, Lisa
dc.contributor.authorO’Meara, Eileen
dc.contributor.authordeKemp, Robert A
dc.contributor.authorKlein, Ran
dc.contributor.authorPaterson, Ian
dc.contributor.authorWhite, James A
dc.contributor.authorYla-Herttuala, Seppo
dc.contributor.authorLeber, Alex
dc.contributor.authorTandon, Vikas
dc.contributor.authorLee, Ting
dc.contributor.authorAl-Hesayen, Abdul
dc.contributor.authorHessian, Renee
dc.contributor.authorDowsley, Taylor
dc.contributor.authorKass, Malek
dc.contributor.authorKelly, Cathy
dc.contributor.authorGarrard, Linda
dc.contributor.authorTardif, Jean-Claude
dc.contributor.authorKnuuti, Juhani
dc.contributor.authorBeanlands, Rob S
dc.contributor.authorWells, George A
dc.contributor.authoron behalf of the IMAGE-HF Investigators
dc.date.accessioned2014-04-05T12:29:58Z
dc.date.available2014-04-05T12:29:58Z
dc.date.issued2013-12-26
dc.date.updated2014-04-05T12:29:58Z
dc.description.abstractAbstract Background The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for coronary artery disease (CAD) and has been demonstrated to have prognostic value. Whether or not CTA can be used in HF patients is unknown. Acknowledging the aging population, the growing prevalence of HF and the increasing financial burden of healthcare, we need to identify non-invasive diagnostic tests that are available, safe, accurate and cost-effective. Methods/Design The proposed study aims to provide insight into the efficacy of CTA in HF patients. A multicenter randomized controlled trial will enroll 250 HF patients requiring coronary anatomical definition. Enrolled patients will be randomized to either CTA or ICA (n = 125 per group) as the first test to define coronary anatomy. The primary outcomes will be collected to determine downstream resource utilization. Secondary outcomes will include the composite clinical events and major adverse cardiac events. In addition, the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA. It is expected that CTA will be a more cost-effective strategy for diagnosis: yielding similar outcomes with fewer procedural risks and improved resource utilization. Trial registration ClinicalTrials.gov, NCT01283659 Team grant #CIF 99470
dc.description.versionPeer Reviewed
dc.identifier.citationTrials. 2013 Dec 26;14(1):443
dc.identifier.doihttp://dx.doi.org/10.1186/1745-6215-14-443
dc.identifier.urihttp://hdl.handle.net/1993/23410
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderBenjamin JW Chow et al.; licensee BioMed Central Ltd.
dc.titleComputed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)
dc.typeJournal Article
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