Versatile surface biofunctionalization of poly(ethylene terephthalate) by interpenetrating polymerization of a butynyl monomer followed by “Click Chemistry”

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dc.contributor.authorLi, Lingdong
dc.contributor.authorZhao, Nan
dc.contributor.authorLiu, Song
dc.date.accessioned2018-10-05T21:05:41Z
dc.date.available2018-10-05T21:05:41Z
dc.date.issued2011-11-27
dc.date.submitted2018-10-05T20:47:09Zen
dc.description.abstractBiofunctionalization of poly(ethylene terephthalate) (PET) is crucial to its medical and biomedical applications such as surgical drapes, vascular grafts and ligament prostheses. To furnish PET with an alkynyl handle, N-(2-methylbut-3-yn-2-yl)acrylamide (MBAA) underwent photo-initiated copolymerization with N,N0-methylenebisacrylamide (MBA) in methanol-swollen PET surface to form a 3- dimensional interpenetrating network (IPN). The alkynyl handle terminated surface was denoted as PMBAA-PET. A region-selective modification could be achieved using an engraved mask during the photo-initiated copolymerization. Several functional azides including dansyl-azide 1, azido-5,5- dimethyl-hydantoin analog 2, per-azido-b-cyclodextrin (per-azido-b-CD) and azido-Bovine Serum Albumin (BSA-N3), were successfully bonded onto PMBAA-PET surface via Huisgen 1,3-dipolar cycloaddition. Kinetic study of the heterogeneous “click” reaction between PMBAA-PET and 1 was investigated using X-ray photoelectron spectroscopy (XPS) and elemental analysis. PMBAA-PET was rendered with effective biocidal activity against a healthcare-associated methicilin-resistant Staphylococcus aureus (HAMRSA) and a multi-drug-resistant Escherichia coli (MDR-E. coli) after 2 was conferred. Meanwhile, accessible CD cavity was determined and the amount of covalently immobilized BSA protein was also quantified after the respective “click” linkages of per-azido-b-CD and BSA-N3 on PMBAA-PET surface were established.en_US
dc.description.sponsorshipthe Manitoba Health Research Council (MHRC) Establishment grant the Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery grant (RGPIN/372048-2009)en_US
dc.identifier.citationLi, L.; Zhao, N.; Liu, S.* Versatile surface biofunctionalization of poly(ethylene terephthalate) (PET) by interpenetrating polymerization of a butynyl monomer followed by “click” chemistry. Polymer 2012; 53(1): 67-78.en_US
dc.identifier.doi10.1016/j.polymer.2011.11.036
dc.identifier.urihttp://hdl.handle.net/1993/33526
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.rightsopen accessen_US
dc.subjectInterpenetrating polymer networken_US
dc.subjectSurface biofunctionalizationen_US
dc.subjectAntibacterial activityen_US
dc.titleVersatile surface biofunctionalization of poly(ethylene terephthalate) by interpenetrating polymerization of a butynyl monomer followed by “Click Chemistry”en_US
dc.typeArticleen_US
local.author.affiliationFaculty of Agricultural and Food Sciencesen_US
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