The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes and Focal Creatine Deposits

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dc.contributor.authorBürklen, Tanja S.
dc.contributor.authorSchlattner, Uwe
dc.contributor.authorHomayouni, Ramin
dc.contributor.authorGough, Kathleen
dc.contributor.authorRak, Margaret
dc.contributor.authorSzeghalmi, Adriana
dc.contributor.authorWallimann, Theo
dc.date.accessioned2014-08-14T07:06:25Z
dc.date.available2014-08-14T07:06:25Z
dc.date.issued2006-4-4
dc.date.updated2014-08-14T07:06:26Z
dc.description.abstractCytosolic brain-type creatine kinase (BB-CK), which is coexpressed with ubiquitous mitochondrial uMtCK, is significantly inactivated by oxidation, in Alzheimer's disease (AD) patients. Since CK has been shown to play a fundamental role in cellular energetics of the brain, any disturbance of this enzyme may exasperate the AD disease process. Mutations in amyloid precursor protein (APP) are associated with early onset AD and result in abnormal processing of APP, and accumulation of Aβ peptide, the main constituent of amyloid plaques in AD brain. Recent data on a direct interaction between APP and the precursor of uMtCK support an emerging relationship between AD, cellular energy levels and mitochondrial function. In addition, recently discovered creatine (Cr) deposits in the brain of transgenic AD mice, as well as in the hippocampus from AD patients, indicate a direct link between perturbed energy state, Cr metabolism and AD. Here, we review the roles of Cr and Cr-related enzymes and consider the potential value of supplementation with Cr, a potent neuroprotective substance. As a hypothesis, we consider whether Cr, if given at an early time point of the disease, may prevent or delay the course of AD-related neurodegeneration.
dc.description.versionPeer Reviewed
dc.identifier.citationTanja S. Bürklen, Uwe Schlattner, Ramin Homayouni, et al., “The Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes and Focal Creatine Deposits,” Journal of Biomedicine and Biotechnology, vol. 2006, Article ID 35936, 11 pages, 2006. doi:10.1155/JBB/2006/35936
dc.identifier.doihttp://dx.doi.org/10.1155/JBB/2006/35936
dc.identifier.urihttp://hdl.handle.net/1993/23784
dc.language.rfc3066en
dc.rightsopen accessen_US
dc.rights.holderCopyright © 2006 Tanja S. Bürklen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.titleThe Creatine Kinase/Creatine Connection to Alzheimer's Disease: CK Inactivation, APP-CK Complexes and Focal Creatine Deposits
dc.typeJournal Article
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